2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR VEGFR
  4. EGFR/VEGFR2-IN-6

EGFR/VEGFR2-IN-6 (Compound 3k) is a dual-functional inhibitor of EGFR and VEGFR2 with IC50s of 10.53 and 3.37 μM for EGFR and VEGFR2, respectively. EGFR/VEGFR2-IN-6 has significant anti-proliferation activity against breast cancer cells, and induces G0/G1 cell cycle arrest and cell apoptosis, especially early apoptosis. EGFR/VEGFR2-IN-6 can be used for cancers research.

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EGFR/VEGFR2-IN-6

EGFR/VEGFR2-IN-6 Estructura química

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EGFR/VEGFR2-IN-6 Related Antibodies

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Descripciòn

EGFR/VEGFR2-IN-6 (Compound 3k) is a dual-functional inhibitor of EGFR and VEGFR2 with IC50s of 10.53 and 3.37 μM for EGFR and VEGFR2, respectively. EGFR/VEGFR2-IN-6 has significant anti-proliferation activity against breast cancer cells, and induces G0/G1 cell cycle arrest and cell apoptosis, especially early apoptosis. EGFR/VEGFR2-IN-6 can be used for cancers research[1].

IC50 & Target[1]

VEGFR2

3.37 μM (IC50)

EGFR

10.53 μM (IC50)

Peso molecular

485.41

Fòrmula

C24H18F3N3O5
SMILES

FC(C1=CC=C(N/N=C/C2=C(OC(C3=CC(OC)=CC(OC)=C3)=C4)C4=CC([N+]([O-])=O)=C2)C=C1)(F)F
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

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EGFR/VEGFR2-IN-6 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

EGFR/VEGFR2-IN-6EGFRVEGFREpidermal growth factor receptorErbB-1HER1Vascular endothelial growth factor receptorVEGFR2Anti-proliferationMCF-7 cellsVero cellsBreast cancerInhibitorinhibitorinhibit

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Nombre del producto:
EGFR/VEGFR2-IN-6
Cat. No.:
HY-175635
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