2. PROTAC Protein Tyrosine Kinase/RTK Apoptosis
  3. PROTACs c-Met/HGFR Apoptosis
  4. PROTAC c-Met Degrader-4

PROTAC c-Met Degrader-4 (compound D15) is a potent orally active PROTAC c-MET degrader. PROTAC c-Met Degrader-4 demonstrates excellent intracellular degradation potency with a DC50 < 0.5 nM. PROTAC c-Met Degrader-4 induces cell cycle arrest and apoptosis, inhibits cell invasion and migration, thereby suppressing cell proliferation. PROTAC c-Met Degrader-4 inhibits the growth of Hs746T xenograft tumors in nude mice. PROTAC c-Met Degrader-4 can be used for cancer research, such as non-small cell lung cancer and gastric cancer.
(Pink: c-Met/HGFR ligand (HY-14721); Blue: Cereblon ligand (HY-W834174); Black: linker).

For research use only. We do not sell to patients.

PROTAC c-Met Degrader-4

PROTAC c-Met Degrader-4 Chemical Structure

CAS No. : 2959535-15-8

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PROTAC c-Met Degrader-4 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC c-Met Degrader-4 (compound D15) is a potent orally active PROTAC c-MET degrader. PROTAC c-Met Degrader-4 demonstrates excellent intracellular degradation potency with a DC50 < 0.5 nM. PROTAC c-Met Degrader-4 induces cell cycle arrest and apoptosis, inhibits cell invasion and migration, thereby suppressing cell proliferation. PROTAC c-Met Degrader-4 inhibits the growth of Hs746T xenograft tumors in nude mice. PROTAC c-Met Degrader-4 can be used for cancer research, such as non-small cell lung cancer and gastric cancer[1]. (Pink: c-Met/HGFR ligand (HY-14721); Blue: Cereblon ligand (HY-W834174); Black: linker).

IC50 & Target[1]

c-Met

<0.5 nM (DC50)

Molecular Weight

860.92

Formula

C47H44N10O7
CAS No.
SMILES

N#CC1=CC=CC(C2=NN(CC3=CC=CC(C4=NC=C(C=N4)OCC5CCN(CC5)CC(N6CCN(CC6)C7=CC=C8C(N(C9C(NC(CC9)=O)=O)C(C8=C7)=O)=O)=O)=C3)C(C=C2)=O)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC c-Met Degrader-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC c-Met Degrader-42959535-15-8PROTACsc-Met/HGFRApoptosisHs746T xenograftnude miceintracellular degradationInhibitorinhibitorinhibit

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