PROTAC c-Met Degrader-4
PROTAC c-Met Degrader-4 (compound D15) is a potent orally active PROTAC c-MET degrader. PROTAC c-Met Degrader-4 demonstrates excellent intracellular degradation potency with a DC50 < 0.5 nM. PROTAC c-Met Degrader-4 induces cell cycle arrest and apoptosis, inhibits cell invasion and migration, thereby suppressing cell proliferation. PROTAC c-Met Degrader-4 inhibits the growth of Hs746T xenograft tumors in nude mice. PROTAC c-Met Degrader-4 can be used for cancer research, such as non-small cell lung cancer and gastric cancer.
(Pink: c-Met/HGFR ligand (HY-14721); Blue: Cereblon ligand (HY-W834174); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2959535-15-8
- Formula: C47H44N10O7
- Molecular Weight:860.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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c-Met <0.5 nM (DC50) |
Chemical Information
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CAS No. 2959535-15-8
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Molecular Weight 860.92
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Formula C47H44N10O7
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SMILES
N#CC1=CC=CC(C2=NN(CC3=CC=CC(C4=NC=C(C=N4)OCC5CCN(CC5)CC(N6CCN(CC6)C7=CC=C8C(N(C9C(NC(CC9)=O)=O)C(C8=C7)=O)=O)=O)=C3)C(C=C2)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC c-Met Degrader-4 Related Classifications
HY-171824 Related Classifications
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