1. Apoptosis
    PI3K/Akt/mTOR
  2. Apoptosis
    PI3K
  3. Ganoderic acid DM

Ganoderic acid DM 

Cat. No.: HY-120140
Handling Instructions

Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis.

For research use only. We do not sell to patients.

Ganoderic acid DM Chemical Structure

Ganoderic acid DM Chemical Structure

CAS No. : 173075-45-1

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[1][2].

In Vitro

Ganoderic acid DM (GADM) effectively inhibits cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells[1].
Ganoderic acid DM especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1). Ganoderic acid DM markedly suppressed the expression of cathepsin K and TRAP mRNA[2].
Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MCF-7 and MDA-MB-231 cells.
Concentration: 0-100 μM.
Incubation Time: 48 h.
Result: Decreased the cell viability in breast cancer cells.

Cell Viability Assay[2]

Cell Line: RAW-D cells.
Concentration: 0-100 μg/mL.
Incubation Time: 0-100 μg/mL.
Result: Clearly suppressed osteoclastogenesis from the RAW 264 cell D-clone.
Molecular Weight

468.67

Formula

C₃₀H₄₄O₄

CAS No.
SMILES

C[[email protected]]12C3=C(CC[[email protected]@]1([[email protected]@](CC2)([H])[[email protected]](C)CC/C=C(C)/C(O)=O)C)[[email protected]@]4([[email protected]@](C(C)(C(CC4)=O)C)([H])CC3=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Ganoderic acid DMApoptosisPI3KPhosphoinositide 3-kinaseOsteoclastogenesisG1cell-cyclearrestbreastcancerlungInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Ganoderic acid DM
Cat. No.:
HY-120140
Quantity:
MCE Japan Authorized Agent: