2. Apoptosis PI3K/Akt/mTOR
  3. Apoptosis PI3K
  4. Ganoderic acid DM

Ganoderic acid DM 

Cat. No.: HY-120140 Purity: 99.65%
COA Handling Instructions

Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis.

For research use only. We do not sell to patients.

Ganoderic acid DM Chemical Structure

Ganoderic acid DM Chemical Structure

CAS No. : 173075-45-1

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5 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

Ganoderic acid DM Related Antibodies

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  • Biological Activity

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  • References

  • Customer Review

Description

Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[1][2].

In Vitro

Ganoderic acid DM (GADM) effectively inhibits cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells[1].
Ganoderic acid DM especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1). Ganoderic acid DM markedly suppressed the expression of cathepsin K and TRAP mRNA[2].
Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ganoderic acid DM Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-7 and MDA-MB-231 cells.
Concentration: 0-100 μM.
Incubation Time: 48 h.
Result: Decreased the cell viability in breast cancer cells.

Cell Viability Assay[2]

Cell Line: RAW-D cells.
Concentration: 0-100 μg/mL.
Incubation Time: 0-100 μg/mL.
Result: Clearly suppressed osteoclastogenesis from the RAW 264 cell D-clone.
Molecular Weight

468.67

Appearance

Solid

Formula

C30H44O4
CAS No.
SMILES

C[C@]12C3=C(CC[C@@]1([C@@](CC2)([H])[C@H](C)CC/C=C(C)/C(O)=O)C)[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC3=O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (106.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1337 mL 10.6685 mL 21.3370 mL
5 mM 0.4267 mL 2.1337 mL 4.2674 mL
10 mM 0.2134 mL 1.0668 mL 2.1337 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 1.25 mg/mL (2.67 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.25 mg/mL (2.67 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1.25 mg/mL (2.67 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.65%

COA (249 KB) HNMR (116 KB) RP-HPLC (190 KB)

Handling Instructions (2659 KB)
References
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Ganoderic acid DM Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Ganoderic acid DM173075-45-1ApoptosisPI3KPhosphoinositide 3-kinaseOsteoclastogenesisG1cell-cyclearrestbreastcancerlungInhibitorinhibitorinhibit

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