PROTAC BET Degrader-16

PROTAC BET Degrader-16 (Compound A10) is a BET PROTAC degrader with a DC50 of 0.31 nM against BRD4, and it preferentially targets BRD4 over other BET family members. PROTAC BET Degrader-16 degrades BRD2, BRD3 and BRD4 via the ubiquitin-proteasome system, a process that requires target binding and recruitment of the CRBN E3 ligase. PROTAC BET Degrader-16 induces cell cycle arrest and promotes apoptosis. PROTAC BET Degrader-16 exerts anti-tumor activity against acute myeloid leukemia.
(Pink: BET Target protein ligand; Blue: Cereblon ligand (HY-A0003); Black: linker (HY-W018678)).

For research use only. We do not sell to patients.

  • CAS No.: 2410947-65-6
  • Formula: C44H45F2N7O9S
  • Molecular Weight:885.93
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

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