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Cat. No.: HY-161957

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Top1/2-IN-1

Top1/2-IN-1 (compound 23) is an orally available dual inhibitor of Top1/2 with antiproliferative activity. Top1/2-IN-1 damages DNA with increased levels of reactive oxygen species, inducing apoptosis and cell cycle arrest in cancer cells. Top1/2-IN-1 exhibits in vivo antitumor activity in xenograft models.

For research use only. We do not sell to patients.

Formula: C₂₁H₂₁N₃O₂
Molecular Weight:347.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Top1/2-IN-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Top1/2^[1]

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.1 μM Compound: 23	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA	[PMID: 39106476]
BEAS-2B	IC₅₀	9.57 μM Compound: 23	Antiproliferative activity against human BEAS-2B cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA Antiproliferative activity against human BEAS-2B cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA	[PMID: 39106476]
DU-145	IC₅₀	0.52 μM Compound: 23	Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA	[PMID: 39106476]
HCT-116	IC₅₀	0.21 μM Compound: 23	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA	[PMID: 39106476]
Huh-7	IC₅₀	0.83 μM Compound: 23	Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA	[PMID: 39106476]
MCF7	IC₅₀	0.35 μM Compound: 23	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA	[PMID: 39106476]
MDA-MB-231	IC₅₀	0.29 μM Compound: 23	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA	[PMID: 39106476]
NCI-H1650	IC₅₀	0.88 μM Compound: 23	Antiproliferative activity against human NCI-H1650 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA Antiproliferative activity against human NCI-H1650 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA	[PMID: 39106476]
NCI-H1975	IC₅₀	0.74 μM Compound: 23	Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA	[PMID: 39106476]
NCI-H2228	IC₅₀	0.88 μM Compound: 23	Antiproliferative activity against human NCI-H2228 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA Antiproliferative activity against human NCI-H2228 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA	[PMID: 39106476]
NCI-H446	IC₅₀	0.09 μM Compound: 23	Antiproliferative activity against human NCI-H446 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA Antiproliferative activity against human NCI-H446 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA	[PMID: 39106476]
PC-3	IC₅₀	0.4 μM Compound: 23	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA	[PMID: 39106476]
PC-9	IC₅₀	0.76 μM Compound: 23	Antiproliferative activity against human PC-9 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA Antiproliferative activity against human PC-9 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT based ELISA	[PMID: 39106476]

Chemical Information

Molecular Weight 347.41
Formula C₂₁H₂₁N₃O₂
SMILES

CN(C)CCCN1C2=C(C=C(OCO3)C3=C2)C4=C1C5=CC=CC=C5C=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Discovery of Indolo[3,2-c]isoquinoline Derivatives as Novel Top1/2 Dual Inhibitors with Orally Efficacious Antitumor Activity and Low Toxicity

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Top1/2-IN-1

All Topoisomerase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Top1/2-IN-1 Related Classifications

HY-161957 Related Classifications