MTBT
Based on 1 publication(s) in Google Scholar
MTBT is an anticancer agent and p38 MAPK activator. MTBT can inhibit tumor cell proliferation, induce cell cycle arrest and apoptosis. MTBT increases the phosphorylation of histone H3 serine in cancer cells, thereby arresting the cell cycle in the M phase. The specific inhibitor of p38 MAPK, Adezmapimod (HY-10256), can abrogate the cell cycle arrest induced by MTBT.
For research use only. We do not sell to patients.
- Purity: 99.61%
- CAS No.: 1110905-26-4
- Formula: C14H11NO2S2
- Molecular Weight:289.37
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Cell Proliferation Compound Library
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High-Throughput Bioactive Compound Library
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Lactylation Compound Library
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Apoptosis Compound Library
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Immunology/Inflammation Compound Library
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MAPK Compound Library
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Anti-Cancer Compound Library
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Publications Citing Use of MedChemExpress (MCE) MTBT
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Biological Activity
MTBT (2 mg/mL) causes more than 50% viability loss in A549, HeLa, and HepG2 cells[1].
MTBT (4.3-17.2 μM; 24 h) can inhibit colony formation in A549, HeLa, and HepG2 cells[1].
MTBT (0-17.28 μM; 0-72 h) can induce cell cycle arrest and apoptosis in A549 cells, and induce phosphorylation of p38[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:4.32 μM
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Incubation Time:0, 1, 5, and 12 h
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Result:Increased the levels of P-p38, with a significant increase in phosphorylation level observed 1 h after treatment.
Chemical Information
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CAS No. 1110905-26-4
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Appearance Solid
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Molecular Weight 289.37
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Formula C14H11NO2S2
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Color Light brown to brown
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SMILES
OC1=CC=C(C=C1O)C2=CSC(C3=C(C=CS3)C)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Curr Eye Res
Kisspeptin Suppresses the Growth of Primary Pterygial Cells via Inhibiting Chemokine (C-X-C Motif) Ligands in Microenvironment. [Abstract]2025 Sep;50(9):894-902. PMID: 40555256
Solvent & Solubility
DMSO : 100 mg/mL (345.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.64 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.64 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4558 mL | 17.2789 mL | 34.5578 mL | 86.3946 mL |
| 5 mM | 0.6912 mL | 3.4558 mL | 6.9116 mL | 17.2789 mL | |
| 10 mM | 0.3456 mL | 1.7279 mL | 3.4558 mL | 8.6395 mL | |
| 15 mM | 0.2304 mL | 1.1519 mL | 2.3039 mL | 5.7596 mL | |
| 20 mM | 0.1728 mL | 0.8639 mL | 1.7279 mL | 4.3197 mL | |
| 25 mM | 0.1382 mL | 0.6912 mL | 1.3823 mL | 3.4558 mL | |
| 30 mM | 0.1152 mL | 0.5760 mL | 1.1519 mL | 2.8798 mL | |
| 40 mM | 0.0864 mL | 0.4320 mL | 0.8639 mL | 2.1599 mL | |
| 50 mM | 0.0691 mL | 0.3456 mL | 0.6912 mL | 1.7279 mL | |
| 60 mM | 0.0576 mL | 0.2880 mL | 0.5760 mL | 1.4399 mL | |
| 80 mM | 0.0432 mL | 0.2160 mL | 0.4320 mL | 1.0799 mL | |
| 100 mM | 0.0346 mL | 0.1728 mL | 0.3456 mL | 0.8639 mL |
MTBT Related Classifications
HY-118034 Related Classifications
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