1. PI3K/Akt/mTOR
    Apoptosis
  2. Akt
    Apoptosis
  3. AKT-IN-12

AKT-IN-12 

Cat. No.: HY-147513
Handling Instructions

AKT-IN-12 (compound 3e) is a potent Akt kinase inhibitor with an IC50 value of 0.55 μM. AKT-IN-12 induces G0/G1 cell cycle arrest and apoptosis. AKT-IN-12 also inhibits p-AKT, p-ERK, and activates p-JNK, JNK. AKT-IN-12 can be used for researching leukemia.

For research use only. We do not sell to patients.

AKT-IN-12 Chemical Structure

AKT-IN-12 Chemical Structure

CAS No. : 2396718-52-6

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Description

AKT-IN-12 (compound 3e) is a potent Akt kinase inhibitor with an IC50 value of 0.55 μM. AKT-IN-12 induces G0/G1 cell cycle arrest and apoptosis. AKT-IN-12 also inhibits p-AKT, p-ERK, and activates p-JNK, JNK. AKT-IN-12 can be used for researching leukemia[1].

IC50 & Target

IC50: 0.55 μM (Akt)[1]

Molecular Weight

722.89

Formula

C42H46N2O7S

CAS No.
SMILES

[H][[email protected]@]12CC3=CC=C(OC4=CC(C[[email protected]]5(C6=C(C(OC(C7CCCS7)=O)=C(C=C6CCN5C)OC)OC8=C(C=C(C2=C8)CCN1C)OC)[H])=CC=C4OC)C=C3

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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AKT-IN-12
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HY-147513
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