AKT-IN-12
Based on 1 publication(s) in Google Scholar
AKT-IN-12 (compound 3e) is a potent Akt kinase inhibitor with an IC50 value of 0.55 μM. AKT-IN-12 induces G0/G1 cell cycle arrest and apoptosis. AKT-IN-12 also inhibits p-AKT, p-ERK, and activates p-JNK, JNK. AKT-IN-12 can be used for researching leukemia.
For research use only. We do not sell to patients.
- CAS No.: 2396718-52-6
- Formula: C42H46N2O7S
- Molecular Weight:722.89
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) AKT-IN-12
More
Biological Activity
IC50: 0.55 μM (Akt)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEL | IC50 |
1.52 μM
Compound: 3e
|
Cytotoxicity against human HEL cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HEL cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 31784186] |
| K562 | IC50 |
1.53 μM
Compound: 3e
|
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 31784186] |
| MCF7 | IC50 |
4.01 μM
Compound: 3e
|
Cytotoxicity against human MCF-7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF-7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 31784186] |
| MDA-MB-231 | IC50 |
1.6 μM
Compound: 3e
|
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 31784186] |
Chemical Information
-
CAS No. 2396718-52-6
-
Molecular Weight 722.89
-
Formula C42H46N2O7S
-
SMILES
[H][C@@]12CC3=CC=C(OC4=CC(C[C@]5(C6=C(C(OC(C7CCCS7)=O)=C(C=C6CCN5C)OC)OC8=C(C=C(C2=C8)CCN1C)OC)[H])=CC=C4OC)C=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Medicine (Baltimore)
The effects of long-term co-exposure to nanocarbon black particles and benzo[a]pyrene on ROS levels and the AKT/P27 signaling pathway in BEAS-2B cells. [Abstract]2025 Jun 27;104(26):e43016. PMID: 40587741
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AKT-IN-12 Related Classifications
HY-147513 Related Classifications
Powered by Bioz