2. Search Result
Search Result
Results for "

β-1,3-glucan synthase

" in MedChemExpress (MCE) Product Catalog:

1139

Inhibitors & Agonists

3

Screening Libraries

8

Fluorescent Dyes

19

Biochemical Assay Reagents

29

Peptides

2

Inhibitory Antibodies

198

Natural
Products

89

Recombinant Proteins

78

Isotope-Labeled Compounds

107

Antibodies

8

Click Chemistry

13

Oligonucleotides

1

GMP Molecules

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W145521
    β-1,3-Glucan
    1 Publications Verification

    β glucan

    		 Biochemical Assay Reagents IKK NO Synthase Bacterial Infection Inflammation/Immunology Cancer
    β-1,3-Glucan (β Glucan) is an orally active polysaccharide composed of glucose polymers. β-1,3-Glucan increase the activity of IKKβ kinase, enhances the production of nitric oxide. β-1,3-Glucan improves resistance to Vibrio harveyi infection. β-1,3-Glucan enhances immune response, promotes blood pressure recovery, reduces lung, kidney and liver damage, inhibits the growth of syngeneic tumors .
    β-1,3-Glucan
  • HY-104032
    Ac-CoA Synthase-IN-1
    5+ Cited Publications

    		 RSV Infection Metabolic Disease
    Ac-CoA Synthase-IN-1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 μM . Ac-CoA Synthase-IN-1 inhibits the respiratory syncytial virus (RSV) .
    Ac-CoA Synthase-IN-1
  • HY-119109
    Laminaran
    1 Publications Verification

    		 Environmental Pollutants Endogenous Metabolite Cancer
    Laminaran is an β-1-3-glucan and a typical ligand for Dectin-1 from Eisenia Bicyclis, has potent immunomodulating, radioprotective, and anticancer activities . Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds . Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy .
    Laminaran
  • HY-107126
    Ibrexafungerp

    MK 3118; SCY-078

    		 Fungal Infection
    Ibrexafungerp (MK 3118) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp can be used for research of Candida and Aspergillus infections .
    Ibrexafungerp
  • HY-107126A
    Ibrexafungerp citrate

    MK 3118 citrate; SCY-078 citrate

    		 Fungal Infection
    Ibrexafungerp citrate (MK 3118 citrate) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp citrate is an investigational agent for the treatment of Candida and Aspergillus infections .
    Ibrexafungerp citrate
  • HY-P3004
    Endo-1,3-β-glucanase

    Lyticase

    		 Endogenous Metabolite Fungal Infection
    Endo-1,3-β-glucanase (Lyticase) is an endoenzyme that can specifically cleave β-1,3-glycosidic bonds. Endo-1,3-β-glucanase recognizes and binds to β-1,3-glucan chains, catalyzing the cleavage of glycosidic bonds and hydrolyzing polysaccharides into oligosaccharides. Endo-1,3-β-glucanase eliminates vaginal Candida. Endo-1,3-β-glucanase can be used in the study of recurrent Candida vaginitis .
    Endo-1,3-β-glucanase
  • HY-P2739
    Citrate synthase

    		Endogenous Metabolite Others
    Citrate synthase is responsible for catalyzing the first reaction of the citric acid cycle: the condensation of acetyl-CoA and oxaloacetate to form citrate. Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix .
    Citrate synthase
  • HY-N6924
    Zingibroside R1
    1 Publications Verification

    		 HIV PIN1 Fungal GLUT Reactive Oxygen Species (ROS) Infection Neurological Disease Metabolic Disease Cancer
    Zingibroside R1 is an orally active triterpene saponin with multiple biological activities including antioxidant, anti-inflammatory, antiviral, and metabolic regulatory properties. Zingibroside R1 reduces the expression of PIN family members, inhibits the expression of PLT1/PLT2, WOX5, SHR, and SCR, disrupts auxin transport and distribution, triggers plant ROS responses, and inhibits root growth. Zingibroside R1 extends the lifespan of Caenorhabditis elegans, enhances its heat stress resistance, and improves its motor ability. Hydrogel derivatives of Zingibroside R1 inhibit the proliferation of Candida albicans by binding to its β-1,3-glucan and exhibit antifungal activity. Zingibroside R1 inhibits GLUT1-mediated uptake and alleviates liver injury. Zingibroside R1 can be used in research related to neurodegenerative diseases, vulvovaginal candidiasis, acute liver injury, Ehrlich ascites tumor and HIV-1 infection .
    Zingibroside R1
  • HY-144267
    Glucosylceramide synthase-IN-2

    		Glucosylceramide Synthase (GCS) Neurological Disease Metabolic Disease
    Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research .
    Glucosylceramide synthase-IN-2
  • HY-144266
    TP-060

    Glucosylceramide synthase-IN-1

    		 Glucosylceramide Synthase (GCS) Neurological Disease Metabolic Disease
    Glucosylceramide synthase-IN-1 (T-036), a chemical probe, a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research .
    TP-060
  • HY-125723
    Echinocandin B

    SL 7810; A-30912 A

    		 Endogenous Metabolite Fungal Antibiotic Infection
    Echinocandin B (SL 7810) is a lipopeptide antifungal antibiotic. Echinocandin B is produced by Aspergillus nidulans. Echinocandin B inhibits β-1,3-glucan activity, thereby blocking the biosynthesis of fungal cell walls. Echinocandin B exhibits activity against a variety of Aspergillus species .
    Echinocandin B
  • HY-E70425
    Sucrose synthase

    		Glycosyltransferase Metabolic Disease
    Sucrose synthase belongs to glycosyltransferases and is a reversible catalyst present in plants, which catalyzes the conversion of sucrose into fructose and UDP-G or ADP-G. Sucrose synthase localizes to the cytoplasm, plasma membrane, cell wall, vacuole and mitochondria of plants. Sucrose synthase regulates sugar metabolism, supports the development of taproots, fruits, seeds and vascular tissues, drives the synthesis of starch, cellulose and callose, and enhances nitrogen fixation capacity. Sucrose synthase mediates signal transduction in plant meristems. Sucrose synthase is associated with plant growth, anaerobic stress tolerance, as well as shoot apical meristem and leaf morphology; overexpression of this enzyme promotes plant growth, increases xylem size, and elevates cellulose and starch contents .
    Sucrose synthase
  • HY-E70078
    Cystathionine β-synthase

    		Biochemical Assay Reagents Others
    Cystathionine β-synthase is an enzyme that catalyzes the condensation of serine and homocysteine to water and cystathionine. Cystathionine β-synthase is a prominent enzyme for the production of hydrogen sulfide (H2S) .
    Cystathionine β-synthase
  • HY-112715
    ATP synthase inhibitor 1

    		ATP Synthase Cardiovascular Disease
    ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F1/FO-ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels .
    ATP synthase inhibitor 1
  • HY-144270
    Glucosylceramide synthase-IN-3

    		Glucosylceramide Synthase (GCS) Neurological Disease Metabolic Disease
    Glucosylceramide synthase-IN-3 (compound BZ1) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 16 nM for human GCS.Glucosylceramide synthase-IN-3 can be used for Gaucher's disease research .
    Glucosylceramide synthase-IN-3
  • HY-146388
    Mtb ATP synthase-IN-1

    		Bacterial ATP Synthase Infection
    Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium .
    Mtb ATP synthase-IN-1
  • HY-145348
    MK-5204

    		Fungal Infection
    MK-5204 is an orally active β-1,3-glucan synthesis inhibitor.
    MK-5204
  • HY-178175
    Chitin synthase-IN-15

    		Insecticide Infection
    Chitin synthase-IN-15 (Compound 6k) is a chitin synthase inhibitor. Chitin synthase-IN-15 has insecticidal efficacy against Plutella xylostella, with LC50 values of 0.789 and 0.951 μg/mL. Chitin synthase-IN-15 induces molting disruptions, larval mortality, and aberrant pupation, thereby effectively mitigating pest populations. Chitin synthase-IN-15 is an insecticidal agent with favorable ecological safety profiles .
    Chitin synthase-IN-15
  • HY-139594
    Polyketide synthase 13-IN-1

    		Bacterial Infection Inflammation/Immunology
    Polyketide synthase 13-IN-1 (compound 32) is a polyketide synthase 13 inhibitor .
    Polyketide synthase 13-IN-1
  • HY-44688
    S.pombe lumazine synthase-IN-1

    		Bacterial Fungal Infection
    S.pombe lumazine synthase-IN-1 is an inhibitor of lumazine synthases with Ki values of 243 μM and 9.6 μM for Schizosaccharomyces pombe and Mycobacterium tuberculosis lumazine synthases, respectively .
    S.pombe lumazine synthase-IN-1
  • HY-150584
    Chitin synthase inhibitor 3

    		Fungal Infection
    Chitin synthase inhibitor 3 (compound 2d) is a potent chitin synthase inhibitor with an IC50 value of 0.16 mM, and MIC of 1 µg/mL against candida albicans. Antifungal activity .
    Chitin synthase inhibitor 3
  • HY-150583
    Chitin synthase inhibitor 2

    		Fungal Inflammation/Immunology
    Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B .
    Chitin synthase inhibitor 2
  • HY-147721
    Dihydropteroate synthase-IN-1

    		Bacterial Infection
    Dihydropteroate synthase-IN-1 (compound 5g) is a potent dihydropteroate synthase (DHPS) inhibitor. Dihydropteroate synthase-IN-1 shows antimicrobial activities and antifungal activity. Dihydropteroate synthase-IN-1 inhibits cytochromes P450. Dihydropteroate synthase-IN-1 can bu used as diagnostic radio imaging material .
    Dihydropteroate synthase-IN-1
  • HY-150686
    Chitin synthase inhibitor 4

    		Fungal Infection
    Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential chitin synthase-based fungicide in agriculture .
    Chitin synthase inhibitor 4
  • HY-144391
    Chitin synthase inhibitor 1

    		Fungal Inflammation/Immunology
    Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor (IC50=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants .
    Chitin synthase inhibitor 1
  • HY-P1113
    Phospho-Glycogen Synthase Peptide-2(substrate)

    		GSK-3 Others
    Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases .
    Phospho-Glycogen Synthase Peptide-2(substrate)
  • HY-P1113A
    Phospho-Glycogen Synthase Peptide-2(substrate) TFA

    		GSK-3 Others
    Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases .
    Phospho-Glycogen Synthase Peptide-2(substrate) TFA
  • HY-107126B
    Ibrexafungerp phosphate

    MK 3118 phosphate; SCY-078 phosphate

    		 Fungal Infection
    Ibrexafungerp phosphate is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp phosphate can be used for research of Candida and Aspergillus infections .
    Ibrexafungerp phosphate
  • HY-P3179
    1,3-β-Glucanase

    		Bacterial Infection
    1,3-β-Glucanase is one of the primary components in C. albicans biofilm extrapolymeric substance (EPS). 1,3-β-Glucanase can degrade β-1,3-glucan so as to disrupt the Candida biofilm matrix and increase the effect of the antimicrobial agent. 1,3-β-Glucanase can be used as an antibiofilm agent .
    1,3-β-Glucanase
  • HY-139595
    Polyketide synthase 13-IN-2

    		Bacterial Infection Inflammation/Immunology
    Polyketide synthase 13-IN-2 (comp 42) is a polyketide synthase 13 inhibitor against Mycobacterium tuberculosis, with an MIC of 0.25 μg/mL .
    Polyketide synthase 13-IN-2
  • HY-151418
    Chitin synthase inhibitor 8

    		Fungal Infection
    Chitin synthase inhibitor 8 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 8 can be used in the research of fungi infection .
    Chitin synthase inhibitor 8
  • HY-151419
    Chitin synthase inhibitor 9

    		Fungal Infection
    Chitin synthase inhibitor 9 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 9 can be used in the research of fungi infection .
    Chitin synthase inhibitor 9
  • HY-151416
    Chitin synthase inhibitor 6

    		Fungal Infection
    Chitin synthase inhibitor 6 (compound 9b) is a potent chitin synthase (CHS) inhibitor with an IC50 value of 0.21 mM. Chitin synthase inhibitor 6 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 6 can be used in the research of fungi infection .
    Chitin synthase inhibitor 6
  • HY-151417
    Chitin synthase inhibitor 7

    		Fungal Infection
    Chitin synthase inhibitor 7 (compound 9c) is a potent chitin synthase (CHS) inhibitor with an IC50 value of 0.37 mM. Chitin synthase inhibitor 7 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 7 can be used in the research of fungi infection .
    Chitin synthase inhibitor 7
  • HY-139596
    Polyketide synthase 13-IN-3

    		Bacterial Infection Inflammation/Immunology
    Polyketide synthase 13-IN-3 (compound 41) is a polyketide synthase 13 inhibitor，with a MIC of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv .
    Polyketide synthase 13-IN-3
  • HY-149585
    Chitin synthase inhibitor 14

    		Fungal Infection
    Chitin synthase inhibitor 14 (compound 4n) is chitin synthase (CHS) inhibitor. Chitin synthase inhibitor 14 has antifungal activity while possessed the potency against drug-resistant fungal variants .
    Chitin synthase inhibitor 14
  • HY-162804
    ATP synthase inhibitor 3

    		Bacterial ATP Synthase Infection
    ATP synthase inhibitor 3 (compound PT6) is an orally active inhibitor of mycobacterial F-ATP synthase (IC50=0.788 μM). ATP synthase inhibitor 3 inhibits the growth of Mycobacterium tuberculosis H37Rv strain (ATCC-27294) in vitro and depletes intracellular ATP levels at an IC50 value of 30μM .
    ATP synthase inhibitor 3
  • HY-151421
    Chitin synthase inhibitor 11

    		Fungal Infection Cancer
    Chitin synthase inhibitor 11 is a chitin synthase inhibitor. Chitin synthase inhibitor 11 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs) .
    Chitin synthase inhibitor 11
  • HY-151420
    Chitin synthase inhibitor 10

    		Fungal Infection Cancer
    Chitin synthase inhibitor 10 is a chitin synthase inhibitor. Chitin synthase inhibitor 10 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.11 mM. Chitin synthase inhibitor 10 also is an antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 10 can be used for the research of invasive fungal infections (IFIs) .
    Chitin synthase inhibitor 10
  • HY-151422
    Chitin synthase inhibitor 12

    		Fungal Infection Cancer
    Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC50 value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs) .
    Chitin synthase inhibitor 12
  • HY-163131
    Glucosylceramide synthase-IN-4

    		Glucosylceramide Synthase (GCS) Neurological Disease
    Glucosylceramide synthase-IN-4 (compound 12) is a potent glucosylceramide synthase (GCS) inhibitor, with an IC50 of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity .
    Glucosylceramide synthase-IN-4
  • HY-163452
    Squalene synthase-IN-2

    		Farnesyl Transferase Metabolic Disease
    Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) is an orally active squalene synthase inhibitor with IC50 values of 3.4, 99 nM for squalene synthase and cholesterol synthesis, respectively. Squalene synthase-IN-2 reduces plasma cholesterol and triglyceride .
    Squalene synthase-IN-2
  • HY-149405
    Squalene synthase-IN-1

    		Others Metabolic Disease
    Squalene synthase-IN-1 (compound 1) is a potent antihyperlipidemic agent acting through Squalene Synthase inhibition. Squalene synthase-IN-1 exhibits an outstanding antioxidant and anti-inflammatory activity. Squalene synthase-IN-1 displays a significant reduction not only of glucose but also of oxidative stress levels, while it did not cause any toxicity .
    Squalene synthase-IN-1
  • HY-E70559
    Prostaglandin D synthase

    		PGE synthase Cardiovascular Disease Cancer
    Prostaglandin D synthase is a biomarker for meningioma cells and coronary artery disease. Lipocalin-type Prostaglandin D synthase (L-PGDS) is present in the atherosclerotic plaque of the human coronary artery and can be detectable in human serum .
    Prostaglandin D synthase
  • HY-155569
    Chitin synthase inhibitor 13

    		Fungal Infection
    Chitin synthase inhibitor 13 (compound 12g) is a non-competitive inhibitor of chitin synthase, with an IC50 of 106.7 μM. Chitin synthase inhibitor 13 exhibits a broad-spectrum of antifungal activity .
    Chitin synthase inhibitor 13
  • HY-151410
    Chitin synthase inhibitor 5

    		Fungal Infection
    Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal .
    Chitin synthase inhibitor 5
  • HY-150983
    ATP synthase inhibitor 2

    		ATP Synthase Bacterial Infection
    ATP synthase inhibitor 2 is a Pseudomonas aeruginosa (PA) ATP synthase inhibitor (IC50=10 μg/mL). ATP synthase inhibitor 2 can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL .
    ATP synthase inhibitor 2
  • HY-147999
    GlcN-6-P Synthase-IN-1

    		Bacterial Fungal Cytochrome P450 Infection
    GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC50 of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform .
    GlcN-6-P Synthase-IN-1
  • HY-150983A
    ATP synthase inhibitor 2 TFA

    		ATP Synthase Bacterial Infection
    ATP synthase inhibitor 2 (Compound 22) TFA is a Pseudomonas aeruginosa (PA) ATP synthase inhibitor (IC50=10 μg/mL). ATP synthase inhibitor 2 TFA can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL .
    ATP synthase inhibitor 2 TFA
  • HY-16108A
    BMS-187745 tripotassium

    		Farnesyl Transferase Metabolic Disease
    BMS-187745 tripotassium (Compound 1) is a potent squalene synthase inhibitor .
    BMS-187745 tripotassium

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: