Squalene synthase-IN-2
Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) is an orally active squalene synthase inhibitor with IC50 values of 3.4, 99 nM for squalene synthase and cholesterol synthesis, respectively. Squalene synthase-IN-2 reduces plasma cholesterol and triglyceride.
For research use only. We do not sell to patients.
- Formula: C31H39ClN2O6
- Molecular Weight:571.10
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 3.4 nM (squalene synthase); 99 nM (cholesterol synthesis)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Hamster and marmoset[1]
-
Dosage:100 mg/kg for hamster, 10 mg/kg for marmoset
-
Administration:P.o.; daily for 14 days for hamster, 7 days for marmoset
-
Result:Demonstrated a significant reduction of non-high-density lipoprotein (HDL) cholesterol by 18% and a reduction of triglyceride (TG) by 16% in marmoset, reduced total cholesterol by 32% and TG by 35% in hamsters.
Chemical Information
-
Molecular Weight 571.10
-
Formula C31H39ClN2O6
-
SMILES
O=C([C@@H]1C[C@H](N(C(C2)=O)CCO[C@H](C3=CC=CC=C3OC)C4=CC(Cl)=CC=C4N(CC(C)(C)C)C2=O)CCC1)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Squalene synthase-IN-2 Related Classifications
HY-163452 Related Classifications
Powered by Bioz