1. Apoptosis
    Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. Apoptosis
    NO Synthase
    Endogenous Metabolite
  3. 7,8-Dihydroneopterin

7,8-Dihydroneopterin 

Cat. No.: HY-136341
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7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases.

For research use only. We do not sell to patients.

7,8-Dihydroneopterin Chemical Structure

7,8-Dihydroneopterin Chemical Structure

CAS No. : 1218-98-0

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Description

7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases[1].

IC50 & Target

Apoptosis; iNOS[1]

In Vitro

7,8-Dihydroneopterin is a heterocyclic pteridine which produced and secreted by monocytes/macrophages upon stimulation with the cytokine interferon-y (IFN-y)[1].
7,8-Dihydroneopterin (0.1, 0.5, 1, 2.5, 5 mM; 2 days and 5 days) inhibits growth of U373MG astroeytes[1] .

Cell Viability Assay[1]

Cell Line: Astrocytic cell line U373MG
Concentration: 0.1, 0.5, 1, 2.5, 5 mM
Incubation Time: 2 days and 5 days
Result: After 2 days of treatment, a significantly lower cell number was observed for those cells treated with 5 mM and 2.5 mM.
After incubation for 5 days concentrations of 1-5 mM completely abrogated acid phosphatase activity to background level found for complete cell culture medium.
A significant cell growth inhibition was also visible for the cells incubated with 0.5 mM, whereas 0.1 mM did not alter cell growth.
Molecular Weight

255.23

Formula

C₉H₁₃N₅O₄

CAS No.

1218-98-0

SMILES

O=C1NC(N)=NC2=C1N=C([[email protected]](O)[[email protected]](O)CO)CN2

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Keywords:

7,8-DihydroneopterinApoptosisNO SynthaseEndogenous MetaboliteNitric oxide synthasesNOSInflammationmarkerapoptosisastrocytesneuronsiNOSneurodegenerativediseasesInhibitorinhibitorinhibit

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7,8-Dihydroneopterin
Cat. No.:
HY-136341
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