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Cat. No.: HY-107531R

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A 1070722 (Standard)

A 1070722 (Standard) is the analytical standard of A 1070722 (HY-107531). This product is intended for research and analytical applications. A 1070722 is a potent and selective glycogen synthase K_inase 3 (GSK-3) inhibitor, with a K_i of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain. A 1070722 decreases spontaneous locomotion.

For research use only. We do not sell to patients.

CAS No.: 1384424-80-9
Formula: C₁₇H₁₃F₃N₄O₂
Molecular Weight:362.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

A 1070722 (Standard) Chemical Structure

CAS No.: 1384424-80-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
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Biological Activity

Description

IC₅₀ & Target

Ki: 0.6 nM (GSK-3)^[1]

All GSK-3 Isoforms :

Chemical Information

CAS No. 1384424-80-9
Molecular Weight 362.31
Formula C₁₇H₁₃F₃N₄O₂
SMILES

FC(F)(F)C1=NC(NC(NC2=CC=NC3=C2C=CC(OC)=C3)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Prabhakaran J, et al. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 Aug 16;8(8):1697-1703. [Content Brief]

[2]. Rocca J F. Effect of glycogen synthase kinase-3 inhibition on the acquisition and expression of cocaine-cue conditioned activity and spontaneous locomotion in rodents. Queen's University (Canada), 2014.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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A 1070722 (Standard)

All GSK-3 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

A 1070722 (Standard) Related Classifications

HY-107531R Related Classifications