1. PI3K/Akt/mTOR
    Stem Cell/Wnt
  2. GSK-3
  3. A 1070722

A 1070722 

Cat. No.: HY-107531 Purity: >99.0%
Handling Instructions

A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain.

For research use only. We do not sell to patients.

A 1070722 Chemical Structure

A 1070722 Chemical Structure

CAS No. : 1384424-80-9

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Description

A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain[1].

IC50 & Target

GSK-3α

0.6 nM (Ki)

GSK-3β

0.6 nM (Ki)

Molecular Weight

362.31

Formula

C₁₇H₁₃F₃N₄O₂

CAS No.

1384424-80-9

SMILES

FC(F)(F)C1=NC(NC(NC2=CC=NC3=C2C=CC(OC)=C3)=O)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

A 1070722A1070722A-1070722GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3Inhibitorinhibitorinhibit

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A 1070722
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HY-107531
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