2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. A 1070722

A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain.

For research use only. We do not sell to patients.

A 1070722 Chemical Structure

A 1070722 Chemical Structure

CAS No. : 1384424-80-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 86 In-stock
Solution
10 mM * 1 mL in DMSO USD 86 In-stock
Solid
5 mg USD 79 In-stock
10 mg USD 127 In-stock
50 mg USD 435 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain[1].

IC50 & Target[1]

GSK-3α

0.6 nM (Ki)

GSK-3β

0.6 nM (Ki)

Molecular Weight

362.31

Formula

C17H13F3N4O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC(F)(F)C1=NC(NC(NC2=CC=NC3=C2C=CC(OC)=C3)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (230.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7601 mL 13.8003 mL 27.6007 mL
5 mM 0.5520 mL 2.7601 mL 5.5201 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.95%

COA (250 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7601 mL 13.8003 mL 27.6007 mL 69.0017 mL
5 mM 0.5520 mL 2.7601 mL 5.5201 mL 13.8003 mL
10 mM 0.2760 mL 1.3800 mL 2.7601 mL 6.9002 mL
15 mM 0.1840 mL 0.9200 mL 1.8400 mL 4.6001 mL
20 mM 0.1380 mL 0.6900 mL 1.3800 mL 3.4501 mL
25 mM 0.1104 mL 0.5520 mL 1.1040 mL 2.7601 mL
30 mM 0.0920 mL 0.4600 mL 0.9200 mL 2.3001 mL
40 mM 0.0690 mL 0.3450 mL 0.6900 mL 1.7250 mL
50 mM 0.0552 mL 0.2760 mL 0.5520 mL 1.3800 mL
60 mM 0.0460 mL 0.2300 mL 0.4600 mL 1.1500 mL
80 mM 0.0345 mL 0.1725 mL 0.3450 mL 0.8625 mL
100 mM 0.0276 mL 0.1380 mL 0.2760 mL 0.6900 mL
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A 1070722 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A 10707221384424-80-9A1070722A-1070722GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3Inhibitorinhibitorinhibit

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