1. Anti-infection
  2. Fungal
  3. Harzianic acid

Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide.

For research use only. We do not sell to patients.

Harzianic acid Chemical Structure

Harzianic acid Chemical Structure

CAS No. : 157148-06-6

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Description

Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide[1][2].

IC50 & Target

Acetohydroxyacid synthase (AHAS)[2]

In Vitro

Harzianic acid shows significant antimicrobial activity against MRSP and MSSP, with MIC values of 32 μg/mL and 16 μg/mL, respectively[1].
Harzianic acid (8-128 μg/mL) exhibits low cytotoxicity on HaCaT cells[1].
Harzianic acid inhibits fungal ThAHAS as a competitive inhibitor with a Ki of 6.65 μM[2].
Harzianic acid (0.1-100 μg/mL) inhibits pathogenic fungi growth[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

365.42

Formula

C19H27NO6

CAS No.
SMILES

CC(C)[C@@](C(O)=O)(O)C[C@H](N1C)C(/C(C1=O)=C(O)\C=C\C=C\CCC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Harzianic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Harzianic acid
Cat. No.:
HY-122950
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