Harzianic acid
Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide.
For research use only. We do not sell to patients.
- CAS No.: 157148-06-6
- Formula: C19H27NO6
- Molecular Weight:365.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Acetohydroxyacid synthase (AHAS)[2]
Harzianic acid shows significant antimicrobial activity against MRSP and MSSP, with MIC values of 32 μg/mL and 16 μg/mL, respectively[1].
Harzianic acid (8-128 μg/mL) exhibits low cytotoxicity on HaCaT cells[1].
Harzianic acid inhibits fungal ThAHAS as a competitive inhibitor with a Ki of 6.65 μM[2].
Harzianic acid (0.1-100 μg/mL) inhibits pathogenic fungi growth[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 157148-06-6
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Molecular Weight 365.42
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Formula C19H27NO6
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SMILES
CC(C)[C@@](C(O)=O)(O)C[C@H](N1C)C(/C(C1=O)=C(O)\C=C\C=C\CCC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. De Filippis A, et al. Antimicrobial activity of harzianic acid against Staphylococcus pseudintermedius. Nat Prod Res. 2021 Dec;35(23):5440-5445. [Content Brief]
[2]. Xie L, et al. Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase. J Am Chem Soc. 2021 Jun 16:10.1021/jacs.1c03988. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Harzianic acid Related Classifications
HY-122950 Related Classifications
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