157148-06-6
Chemical Structure
Harzianic acid
- CAS No.: 157148-06-6
- Formula:C19H27NO6
- Molecular Weight:365.42
IUPAC Name: (S)-2-hydroxy-2-(((S,Z)-4-((2E,4E)-1-hydroxyocta-2,4-dien-1-ylidene)-1-methyl-3,5-dioxopyrrolidin-2-yl)methyl)-3-methylbutanoic acid
InChIKey: FQSWTHMMNDRFAI-GOVSHCJESA-N
SMILES: CC(C)[C@@](C(O)=O)(O)C[C@H](N1C)C(/C(C1=O)=C(O)\C=C\C=C\CCC)=O
Biological Activity: Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide[1][2].
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Harzianic acid | Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide. | |||||||||||||||||||||
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References
- [1]. De Filippis A, et al. Antimicrobial activity of harzianic acid against Staphylococcus pseudintermedius. Nat Prod Res. 2021 Dec;35(23):5440-5445. [Content Brief]
- [2]. Xie L, et al. Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase. J Am Chem Soc. 2021 Jun 16:10.1021/jacs.1c03988. [Content Brief]
