Art. -Nr.: HY-B0869

Bispyribac

Name: Bispyribac
Brand: MedChemExpress
SKU: HY-B0869
Price: 90.00 USD
Availability: InStock
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Bispyribac is an acetolactate synthase inhibitor that can be used as a systemic post-emergence herbicide for control of weeds in agriculture. Bispyribac blocks the amino acid synthesis. Bispyribac has low acute toxicity in animal models.

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CAS. Nr.: 125401-75-4
Formel: C₁₉H₁₈N₄O₈
Molecular Weight:430.37

Speicherung:

Store at room temperature, keep dry and cool.

In solvent -80°C, 1 year , -20°C, 6 months

Bispyribac Chemical Structure

CAS. Nr.: 125401-75-4

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vivo

Bispyribac (p.o.; single dose) exhibits an acute oral LD₅₀ of 4111 mg/kg in male rats and 2635 mg/kg in female rats, and exhibits an acute oral LD₅₀ of 3524 mg/kg in male and female mice, indicating low acute oral toxicity^[1].
Bispyribac (enteral; single dose) reaches peak plasma concentrations 1-2 hours after enteral administration in Rattus norvegicus, has an apparent elimination half-life of 5-7 hours, and is primarily eliminated unchanged in feces via biliary excretion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rats^[1]
Dosage:

4111 mg/kg (male rats); 2635 mg/kg (female rats)
Administration:

p.o.; single dose
Result:

Determined an acute oral LD₅₀ of 4111 mg/kg in male rats.
Determined an acute oral LD₅₀ of 2635 mg/kg in female rats.

Animal Model:

Mice^[1]
Dosage:

3524 mg/kg
Administration:

p.o.; single dose
Result:

Determined an acute oral LD₅₀ of 3524 mg/kg in male and female mice.

Chemical Information

CAS. Nr. 125401-75-4
Appearance Solid
Molecular Weight 430.37
Formel C₁₉H₁₈N₄O₈
SMILES

O=C(C1=C(OC2=NC(OC)=CC(OC)=N2)C=CC=C1OC3=NC(OC)=CC(OC)=N3)O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 5 mg/mL (11.62 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3236 mL

11.6179 mL

23.2358 mL

5 mM

0.4647 mL

2.3236 mL

4.6472 mL

10 mM

0.2324 mL

1.1618 mL

2.3236 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 0.5 mg/mL (1.16 mM); Clear solution

This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 0.5 mg/mL (1.16 mM); Clear solution

This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 0.5 mg/mL (1.16 mM); Clear solution

This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Bandara Gawarammana I, et al. Acute human self-poisoning with bispyribac-containing herbicide Nominee: a prospective observational study. Clin Toxicol (Phila). 2010;48(3):198-202. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3236 mL	11.6179 mL	23.2358 mL	58.0896 mL
	5 mM	0.4647 mL	2.3236 mL	4.6472 mL	11.6179 mL
	10 mM	0.2324 mL	1.1618 mL	2.3236 mL	5.8090 mL

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Bispyribac