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Cat. No.: HY-183551

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Antitubercular agent-59

Antitubercular agent-59 is an orally active antitubercular agent with an IC₅₀ of 51 nM against Mycobacterium tuberculosis H37Rv. Antitubercular agent-59 inhibits growth of Bedaquiline (HY-14881)-resistant Rv0678^G12C mutant strains. Antitubercular agent-59 exerts bactericidal activity in chronic tuberculosis mouse models with 1-Aminobenzotriazole (HY-103389) coadministration.

For research use only. We do not sell to patients.

Formula: C₂₂H₂₃N₃O₃
Molecular Weight:377.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antitubercular agent-59 Chemical Structure

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

In Vitro

Antitubercular agent-59 (Compound 6k) potently inhibits the growth of Mycobacterium tuberculosis H37Rv whole cells with an IC₅₀ of 213 nM^[1].
Antitubercular agent-59 shows moderate metabolic clearance in rat hepatocytes and human liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitubercular agent-59 (Compound 6k) (100 mg/kg; i.g.; daily 5 days per week; 4 weeks) exhibits bactericidal activity coadministered with 1-Aminobenzotriazole (HY-103389) in chronic mouse infection model of TB^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Chronic mouse infection model of TB^[1]
Dosage:

100 mg/kg
Administration:

I.g.; daily 5 days per week; 4 weeks
Result:

Reduced CFU counts to 5.18 log10 CFU/lung when treated with 1-Aminobenzotriazole (100 mg/kg).
Had a mean log10 CFU/lung of 5.97, which was not significantly different from that of untreated control when treated with 6k alone at 100 mg/kg.

Chemical Information

Molecular Weight 377.44
Formula C₂₂H₂₃N₃O₃
SMILES

O=C1C(C(C2=CC=C(N3C[C@@H](C)O[C@@H](C)C3)C=C2)=C1NCC4=NC=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mosallam N, et al. Second-Generation Anti-Tubercular Squaramides Targeting Complex V of the Respiratory Chain of Mycobacterium tuberculosis Displaying Enhanced Metabolic Stability. J Med Chem. 2026 May 14;69(9):10213-10239. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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