2. Anti-infection
  3. Bacterial
  4. Antitubercular agent-59

Antitubercular agent-59 is an orally active antitubercular agent with an IC50 of 51 nM against Mycobacterium tuberculosis H37Rv. Antitubercular agent-59 inhibits growth of Bedaquiline (HY-14881)-resistant Rv0678G12C mutant strains. Antitubercular agent-59 exerts bactericidal activity in chronic tuberculosis mouse models with 1-Aminobenzotriazole (HY-103389) coadministration.

For research use only. We do not sell to patients.

Antitubercular agent-59

Antitubercular agent-59 Chemical Structure

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Antitubercular agent-59 Related Antibodies

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Description

Antitubercular agent-59 is an orally active antitubercular agent with an IC50 of 51 nM against Mycobacterium tuberculosis H37Rv. Antitubercular agent-59 inhibits growth of Bedaquiline (HY-14881)-resistant Rv0678G12C mutant strains. Antitubercular agent-59 exerts bactericidal activity in chronic tuberculosis mouse models with 1-Aminobenzotriazole (HY-103389) coadministration[1].

In Vitro

Antitubercular agent-59 (Compound 6k) potently inhibits the growth of Mycobacterium tuberculosis H37Rv whole cells with an IC50 of 213 nM[1].
Antitubercular agent-59 shows moderate metabolic clearance in rat hepatocytes and human liver microsomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitubercular agent-59 Related Antibodies
In Vivo

Antitubercular agent-59 (Compound 6k) (100 mg/kg; i.g.; daily 5 days per week; 4 weeks) exhibits bactericidal activity coadministered with 1-Aminobenzotriazole (HY-103389) in chronic mouse infection model of TB[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chronic mouse infection model of TB[1]
Dosage: 100 mg/kg
Administration: I.g.; daily 5 days per week; 4 weeks
Result: Reduced CFU counts to 5.18 log10 CFU/lung when treated with 1-Aminobenzotriazole (100 mg/kg).
Had a mean log10 CFU/lung of 5.97, which was not significantly different from that of untreated control when treated with 6k alone at 100 mg/kg.
Molecular Weight

377.44

Formula

C22H23N3O3
SMILES

O=C1C(C(C2=CC=C(N3C[C@@H](C)O[C@@H](C)C3)C=C2)=C1NCC4=NC=CC=C4)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitubercular agent-59 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitubercular agent-59Antitubercular agent59Antitubercular agent 59Bacterialtuberculosisbedaquiline-resistant Rv0678 mutant strainschronic tuberculosis mouse modelsATP synthaseMmpS5-MmpL5 pumpRv06781-aminobenzotriazoleMycobacterium tuberculosisInhibitorinhibitorinhibit

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