1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
    Apoptosis
  2. EGFR
    Thymidylate Synthase
    Apoptosis
  3. EGFR/HER2/TS-IN-1

EGFR/HER2/TS-IN-1 

Cat. No.: HY-146238
Handling Instructions

EGFR/HER2/TS-IN-1 (Compound 4d) is an EGFR, HER2 and TS (Thymidylate synthase) inhibitor with IC50 values of 0.203, 0.088 and 0.168 μM against EGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cell apoptosis.

For research use only. We do not sell to patients.

EGFR/HER2/TS-IN-1 Chemical Structure

EGFR/HER2/TS-IN-1 Chemical Structure

CAS No. : 2444363-11-3

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Description

EGFR/HER2/TS-IN-1 (Compound 4d) is an EGFR, HER2 and TS (Thymidylate synthase) inhibitor with IC50 values of 0.203, 0.088 and 0.168 μM against EGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cell apoptosis[1].

IC50 & Target

HER2

0.088 μM (IC50)

Thymidylate synthase

0.168 μM (IC50)

EGFR

0.203 μM (IC50)

In Vitro

EGFR/HER2/TS-IN-1 (Compound 4d) shows cytotoxicity with an IC50 of 0.693 μM against MCF7 cells[1].
EGFR/HER2/TS-IN-1 (10 μg, 24 h) arrests cell cycle at G2/M phase and induces cell apoptosis in MCF7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MCF7
Concentration: 10 μg
Incubation Time: 24 h
Result: Arrested cell cycle at G2/M phase.

Apoptosis Analysis[1]

Cell Line: MCF7
Concentration: 10 μg
Incubation Time: 24 h
Result: Induced cell apoptosis.
Molecular Weight

501.54

Formula

C24H15N5O4S2

CAS No.
SMILES

N#CC1=C(C2=COC3=C(C2=O)C=CC=C3)NC(SCC(NC4=NC5=C(S4)C=C(C)C=C5)=O)=NC1=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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EGFR/HER2/TS-IN-1
Cat. No.:
HY-146238
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