EGFR/HER2/TS-IN-1
EGFR/HER2/TS-IN-1 (Compound 4d) is an EGFR, HER2 and TS (Thymidylate synthase) inhibitor with IC50 values of 0.203, 0.088 and 0.168 μM against EGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cell apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2444363-11-3
- Formula: C24H15N5O4S2
- Molecular Weight:501.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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HER2 0.088 μM (IC50) |
Thymidylate synthase 0.168 μM (IC50) |
EGFR 0.203 μM (IC50) |
EGFR/HER2/TS-IN-1 (Compound 4d) shows cytotoxicity with an IC50 of 0.693 μM against MCF7 cells[1].
EGFR/HER2/TS-IN-1 (10 μg, 24 h) arrests cell cycle at G2/M phase and induces cell apoptosis in MCF7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2444363-11-3
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Molecular Weight 501.54
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Formula C24H15N5O4S2
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SMILES
N#CC1=C(C2=COC3=C(C2=O)C=CC=C3)NC(SCC(NC4=NC5=C(S4)C=C(C)C=C5)=O)=NC1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR/HER2/TS-IN-1 Related Classifications
HY-146238 Related Classifications
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