2444363-11-3
2444363-11-3
Chemical Structure
EGFR/HER2/TS-IN-1
- CAS No.: 2444363-11-3
- Formula:C24H15N5O4S2
- Molecular Weight:501.54
IUPAC Name: 2-((5-cyano-4-oxo-6-(4-oxo-4H-chromen-3-yl)-1,4-dihydropyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
InChIKey: KVHGAEBTDZLAAL-UHFFFAOYSA-N
SMILES: N#CC1=C(C2=COC3=C(C2=O)C=CC=C3)NC(SCC(NC4=NC5=C(S4)C=C(C)C=C5)=O)=NC1=O
Biological Activity: EGFR/HER2/TS-IN-1 (Compound 4d) is an EGFR, HER2 and TS (Thymidylate synthase) inhibitor with IC50 values of 0.203, 0.088 and 0.168 μM against EGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cell apoptosis[1].
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EGFR/HER2/TS-IN-1 | EGFR/HER2/TS-IN-1 (Compound 4d) is an EGFR, HER2 and TS (Thymidylate synthase) inhibitor with IC50 values of 0.203, 0.088 and 0.168 μM against EGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cell apoptosis. | |||||||||||||||||||||
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References
Keywords
