S.pombe lumazine synthase-IN-1
Based on 1 Customer Validation
S.pombe lumazine synthase-IN-1 is an inhibitor of lumazine synthases with Ki values of 243 μM and 9.6 μM for Schizosaccharomyces pombe and Mycobacterium tuberculosis lumazine synthases, respectively.
For research use only. We do not sell to patients.
- Purity : 99.72%
- CAS No.: 331726-35-3
- Formula: C14H13N3O6
- Molecular Weight:319.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
Ki: 243 μM (Schizosaccharomyces pombe lumazine synthase); 9.6 μM (Mycobacterium tuberculosis lumazine synthase)[1]
In Vitro
S.pombe lumazine synthase-IN-1 (Compound 21) is a class II compound with OCH3 groups displays slightly better potencies than its counterparts with OH groups[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 331726-35-3
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Appearance Solid
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Molecular Weight 319.27
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Formula C14H13N3O6
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Color Light yellow to yellow
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SMILES
O=C1NC(C([N+]([O-])=O)=C(/C=C/C2=CC=C(OC)C(OC)=C2)N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 31.25 mg/mL (97.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (285 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1321 mL | 15.6607 mL | 31.3215 mL | 78.3036 mL |
| 5 mM | 0.6264 mL | 3.1321 mL | 6.2643 mL | 15.6607 mL | |
| 10 mM | 0.3132 mL | 1.5661 mL | 3.1321 mL | 7.8304 mL | |
| 15 mM | 0.2088 mL | 1.0440 mL | 2.0881 mL | 5.2202 mL | |
| 20 mM | 0.1566 mL | 0.7830 mL | 1.5661 mL | 3.9152 mL | |
| 25 mM | 0.1253 mL | 0.6264 mL | 1.2529 mL | 3.1321 mL | |
| 30 mM | 0.1044 mL | 0.5220 mL | 1.0440 mL | 2.6101 mL | |
| 40 mM | 0.0783 mL | 0.3915 mL | 0.7830 mL | 1.9576 mL | |
| 50 mM | 0.0626 mL | 0.3132 mL | 0.6264 mL | 1.5661 mL | |
| 60 mM | 0.0522 mL | 0.2610 mL | 0.5220 mL | 1.3051 mL | |
| 80 mM | 0.0392 mL | 0.1958 mL | 0.3915 mL | 0.9788 mL |
S.pombe lumazine synthase-IN-1 Related Classifications
HY-44688 Related Classifications
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