2. Metabolic Enzyme/Protease
  3. Farnesyl Transferase
  4. BPH252

BPH252 (Compound 4) is a geranylgeranyl diphosphate synthase inhibitor. BPH252 can be used in research on bisphosphonate-based anticancer inhibitors.

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BPH252

BPH252 화학구조

CAS No. : 2809-23-6

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BPH252 Related Antibodies

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제품 설명

BPH252 (Compound 4) is a geranylgeranyl diphosphate synthase inhibitor. BPH252 can be used in research on bisphosphonate-based anticancer inhibitors[1].

Cellular Effect
Cell Line Type Value Description References
Erythrocyte IC50
0.83 μM
Compound: NBP8
Antiparasitic activity against Plasmodium falciparum 3D7 infected in human erythrocyte assessed as intraerythrocytic growth inhibition incubated for 24 hrs followed by [3H]hypoxanthine addition by microbeta scintillation counter analysis
Antiparasitic activity against Plasmodium falciparum 3D7 infected in human erythrocyte assessed as intraerythrocytic growth inhibition incubated for 24 hrs followed by [3H]hypoxanthine addition by microbeta scintillation counter analysis
[PMID: 33522236]
HFF IC50
0.55 μM
Compound: 2
In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells)
In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells)
[PMID: 15857119]
HFF IC50
0.57 μM
Compound: 2
Inhibitory concentration against the growth of Toxoplasma gondii overexpressing FPPS enzyme in human foreskin fibroblast monolayer cells; (control = 0.15 uM, experiment 2)
Inhibitory concentration against the growth of Toxoplasma gondii overexpressing FPPS enzyme in human foreskin fibroblast monolayer cells; (control = 0.15 uM, experiment 2)
[PMID: 15857119]
HFF IC50
1.7 μM
Compound: 2
Inhibitory concentration against the growth of Toxoplasma gondii overexpressing FPPS enzyme in human foreskin fibroblast monolayer cells; (control = 0.55 uM, experiment 3)
Inhibitory concentration against the growth of Toxoplasma gondii overexpressing FPPS enzyme in human foreskin fibroblast monolayer cells; (control = 0.55 uM, experiment 3)
[PMID: 15857119]
HFF IC50
1.9 μM
Compound: 2
Inhibitory concentration against the growth of Toxoplasma gondii overexpressing FPPS enzyme in human foreskin fibroblast monolayer cells; (control = 0.62 uM, experiment 1)
Inhibitory concentration against the growth of Toxoplasma gondii overexpressing FPPS enzyme in human foreskin fibroblast monolayer cells; (control = 0.62 uM, experiment 1)
[PMID: 15857119]
KB ED50
892 μM
Compound: 72
Dose to inhibit the growth of human KB carcinoma cell line
Dose to inhibit the growth of human KB carcinoma cell line
[PMID: 16162013]
분자량

318.24

화학식

C10H24O7P2
CAS No.
SMILES

O=P(O)(O)C(O)(CCCCCCCCC)P(=O)(O)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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BPH252 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPH2522809-23-6BPH 252BPH-252Farnesyl TransferaseFtaseGGPPcancerInhibitorinhibitorinhibit

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상품명:
BPH252
Cat. No.:
HY-126472
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