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Cat. No.: HY-144391

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Chitin synthase inhibitor 1

Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor (IC₅₀=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants.

For research use only. We do not sell to patients.

CAS No.: 2763387-69-3
Formula: C₂₂H₂₀ClN₃O₃
Molecular Weight:409.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Chitin synthase inhibitor 1 Chemical Structure

CAS No.: 2763387-69-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 0.12 mM (CHS)^[1]

In Vitro

Chitin synthase inhibitor 1 (compound 5a) shows broad-spectrum antifungal activity (MIC=4 μg/mL in Candidaalbicans (C. albicans) ATCC 76615 and Aspergillus fumigatus (A. fumigatus) GIMCC 3.19; MIC=8 μg/mL in Aspergillus flavus (A. flavus) ATCC 16870 and Crytococcusneoformans (C. neoformans) ATCC 32719)^[1].
Chitin synthase inhibitor 1 shows antifungal activity against drug-resistant fungi variants (MIC=32 μg/mL in FluconazoleresistantC.albicans ATCC 76615R, Fluconazole-resistant A.fumigatus GIMCC 3.19R, and Fluconazole-resistant C. neoformans ATCC 32719R, Micafunginresistant C.albicans ATCC 76615R’; MIC=16 μg/mL in Fluconazole-resistant A.flavus ATCC 16870R)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2763387-69-3
Molecular Weight 409.87
Formula C₂₂H₂₀ClN₃O₃
SMILES

O=C(NC1=CC=CC=C1Cl)/C=C/C(N2C3(C(NC4=C(C=CC=C4)C3)=O)CCC2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu H, et al. Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2022, 233:114208. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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