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  3. Chitin synthase inhibitor 1

Chitin synthase inhibitor 1 

Cat. No.: HY-144391
Handling Instructions

Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor (IC50=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants.

For research use only. We do not sell to patients.

Chitin synthase inhibitor 1 Chemical Structure

Chitin synthase inhibitor 1 Chemical Structure

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Description

Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor (IC50=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants[1].

IC50 & Target

IC50: 0.12 mM (CHS)[1]

In Vitro

Chitin synthase inhibitor 1 (compound 5a) shows broad-spectrum antifungal activity (MIC=4 µg/mL in Candidaalbicans (C. albicans) ATCC 76615 and Aspergillus fumigatus (A. fumigatus) GIMCC 3.19; MIC=8 µg/mL in Aspergillus flavus (A. flavus) ATCC 16870 and Crytococcusneoformans (C. neoformans) ATCC 32719)[1].
Chitin synthase inhibitor 1 shows antifungal activity against drug-resistant fungi variants (MIC=32 µg/mL in FluconazoleresistantC.albicans ATCC 76615R, Fluconazole-resistant A.fumigatus GIMCC 3.19R, and Fluconazole-resistant C. neoformans ATCC 32719R, Micafunginresistant C.albicans ATCC 76615R’; MIC=16 µg/mL in Fluconazole-resistant A.flavus ATCC 16870R)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

409.87

Formula

C22H20ClN3O3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Chitin synthase inhibitor 1
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HY-144391
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