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Cat. No.: HY-13475

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mPGES1-IN-8

mPGES1-IN-8, is a novel microsomal prostaglandin E synthase 1 (mPGES1) inhibitor.

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CAS No.: 1381846-21-4
화학식: C₁₆H₁₉ClN₄O₂
분자량:334.80

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

mPGES1-IN-8 Chemical Structure

CAS No.: 1381846-21-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
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Calculators
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Biological Activity

제품 설명

mPGES1-IN-8, is a novel microsomal prostaglandin E synthase 1 (mPGES1) inhibitor^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.87 μM Compound: 26	Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta by EIA method Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta by EIA method	[PMID: 26653180]

Chemical Information

CAS No. 1381846-21-4
분자량 334.80
화학식 C₁₆H₁₉ClN₄O₂
SMILES

O=C(NC1=NC=CN1)C2=CC(CNC(C(C)(C)C)=O)=CC=C2Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jin Y, et al. Dose-dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor. Br J Clin Pharmacol. 2018 Jan;84(1):179-188. [Content Brief]

Calculators

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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mPGES1-IN-8

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Biological Activity

Chemical Information

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References

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mPGES1-IN-8 Related Classifications

HY-13475 Related Classifications