ONO-1714
ONO-1714 is an orally active nitric oxide synthase inhibitor. ONO-1714 attenuates endotoxin-induced acute lung injury, reduces intestinal ischemia–reperfusion injury, represses biliary carcinogenesis.
For research use only. We do not sell to patients.
- CAS No.: 214479-33-1
- Formula: C7H12Cl2N2
- Molecular Weight:195.09
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Peritoneal macrophage cell | IC50 |
0.82 μM
Compound: 6, ONO-1714
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Inhibition of LPS/INFgamma-induced nitric oxide production in CD-1 mouse peritoneal macrophages after 48 hrs by Griess reaction
Inhibition of LPS/INFgamma-induced nitric oxide production in CD-1 mouse peritoneal macrophages after 48 hrs by Griess reaction
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[PMID: 22703704] |
Chemical Information
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CAS No. 214479-33-1
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Molecular Weight 195.09
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Formula C7H12Cl2N2
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SMILES
Cl[C@@H]1[C@@]2([H])[C@]1([H])N=C(C[C@@H]2C)N.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Inhalation Toxicity Study
Inhalation toxicity studies expose rodents to a controlled aerosol, vapor, gas, or smoke atmosphere and assess respiratory and systemic toxicity using exposure-atmosphere characterization, clinical observations, body and organ weights, bronchoalveolar lavage fluid, histopathology, blood chemistry, hematology, and, when included, molecular endpoints such as transcriptomics, proteomics, lipidomics, or tissue burden analysis. The primary biological readouts are airway irritation, pulmonary inflammation, cytotoxicity, altered surfactant or lipid homeostasis, impaired particle clearance, and tissue remodeling, reflected by BALF cell differentials, BALF protein, LDH, phosphatase activities, cytokines, lung weight, microscopic respiratory-tract lesions, and retained lung burden.
Purity & Documentation
References
[1]. Mishima T, et al. Chemopreventative effect of an inducible nitric oxide synthase inhibitor, ONO-1714, on inflammation-associated biliary carcinogenesis in hamsters. Carcinogenesis. 2009 Oct;30(10):1763-7. [Content Brief]
[2]. Naito Y, et al. A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats. Nitric Oxide. 2004 May;10(3):170-7. [Content Brief]
[3]. Mikawa K, et al. ONO-1714, a nitric oxide synthase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits. Anesth Analg. 2003 Dec;97(6):1751-1755. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ONO-1714 Related Classifications
HY-106162A Related Classifications
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