214479-33-1
214479-33-1
Chemical Structure
ONO-1714
- CAS No.: 214479-33-1
- Formula:C7H12Cl2N2
- Molecular Weight:195.09
IUPAC Name: (1S,5S,6R,7R)-7-chloro-5-methyl-2-azabicyclo[4.1.0]hept-2-en-3-amine hydrochloride
InChIKey: IZIZKGZAEABSET-IEUZAGAGSA-N
SMILES: Cl[C@@H]1[C@@]2([H])[C@]1([H])N=C(C[C@@H]2C)N.Cl
Biological Activity: ONO-1714 is an orally active nitric oxide synthase inhibitor. ONO-1714 attenuates endotoxin-induced acute lung injury, reduces intestinal ischemia–reperfusion injury, represses biliary carcinogenesis[1][2][3].
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ONO-1714 | ONO-1714 is an orally active nitric oxide synthase inhibitor. ONO-1714 attenuates endotoxin-induced acute lung injury, reduces intestinal ischemia–reperfusion injury, represses biliary carcinogenesis. | |||||||||||||||||||||
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References
- [1]. Mishima T, et al. Chemopreventative effect of an inducible nitric oxide synthase inhibitor, ONO-1714, on inflammation-associated biliary carcinogenesis in hamsters. Carcinogenesis. 2009 Oct;30(10):1763-7. [Content Brief]
- [2]. Naito Y, et al. A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats. Nitric Oxide. 2004 May;10(3):170-7. [Content Brief]
- [3]. Mikawa K, et al. ONO-1714, a nitric oxide synthase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits. Anesth Analg. 2003 Dec;97(6):1751-1755. [Content Brief]
Keywords
