cGAS-IN-7
cGAS-IN-7 is a cyclic GMP-AMP synthase (cGAS) inhibitor with an IC50 of 0.66 μM for human cGAS. cGAS-IN-7 modestly decreases cGAMP levels in THP1 cells. cGAS-IN-7 can be used for the research of Alzheimer's disease.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C16H15BrINO4S
- Peso molecular:524.17
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
cGAS-IN-7 (compound 6) (10 μM, 20 μM; 3 hours) exhibits varying levels of cGAS inhibition in cell-free assays[1].
cGAS-IN-7 (10 μM, 30 μM, 100 μM; 16 hours) demonstrates significant inhibition of cGAS activity and downstream signaling in THP1 Dual cells. cGAS-IN-7 reduces IFN levels, but it does not affect NF-kB levels at 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 524.17
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Fòrmula C16H15BrINO4S
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SMILES
O=C(NS(=O)(C1=CC=C(OCC)C(Br)=C1)=O)CC2=CC=C(I)C=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
cGAS-IN-7 Related Classifications
HY-179624 Related Classifications
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