cGAS-IN-7
cGAS-IN-7 is a cyclic GMP-AMP synthase (cGAS) inhibitor with an IC50 of 0.66 μM for human cGAS. cGAS-IN-7 modestly decreases cGAMP levels in THP1 cells. cGAS-IN-7 can be used for the research of Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C16H15BrINO4S
- Molecular Weight:524.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
cGAS-IN-7 (compound 6) (10 μM, 20 μM; 3 hours) exhibits varying levels of cGAS inhibition in cell-free assays[1].
cGAS-IN-7 (10 μM, 30 μM, 100 μM; 16 hours) demonstrates significant inhibition of cGAS activity and downstream signaling in THP1 Dual cells. cGAS-IN-7 reduces IFN levels, but it does not affect NF-kB levels at 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 524.17
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Formula C16H15BrINO4S
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SMILES
O=C(NS(=O)(C1=CC=C(OCC)C(Br)=C1)=O)CC2=CC=C(I)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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