2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Apoptosis PI3K/Akt/mTOR
  3. Fatty Acid Synthase (FASN) Reactive Oxygen Species (ROS) Apoptosis PI3K Akt Caspase
  4. FASN-IN-8

FASN-IN-8 is a fatty acid synthase (FASN) inhibitor. FASN-IN-8 inhibits FASN-mediated de novo lipogenesis. FASN-IN-8 blocks PI3K/AKT pathway activation, inhibits cancer cells proliferation, migration and invasion. FASN-IN-8 induces apoptosis and ROS production. FASN-IN-8 can be used for the research of hepatocellular carcinoma.

For research use only. We do not sell to patients.

FASN-IN-8

FASN-IN-8 Chemical Structure

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FASN-IN-8 Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

FASN-IN-8 is a fatty acid synthase (FASN) inhibitor. FASN-IN-8 inhibits FASN-mediated de novo lipogenesis. FASN-IN-8 blocks PI3K/AKT pathway activation, inhibits cancer cells proliferation, migration and invasion. FASN-IN-8 induces apoptosis and ROS production. FASN-IN-8 can be used for the research of hepatocellular carcinoma[1].

IC50 & Target[1]

Caspase 3

 

Caspase 9

 

In Vitro

FASN-IN-8 (Compound 4) (48 h) potently inhibits proliferation of Hep-G2 hepatocellular carcinoma cells with an IC50 of 0.47 μM, shows lower activity against Huh-7 cells with an IC50 of 1.43 μM, and has high selectivity for cancer cells over normal HUVECs with a selectivity index of 260[1].
FASN-IN-8 (0.094-2.35 μM; 24 h) inhibits colony formation of Hep-G2 cells in a concentration-dependent manner[1].
FASN-IN-8 (0.094-2.35 μM; 24 h) dose-dependently inhibits FASN activity in Hep-G2 cells[1].
FASN-IN-8 (0.094-2.35 μM; 48 h) induces caspase-mediated apoptosis in Hep-G2 cells in a concentration-dependent manner, with upregulated cleaved-caspase-3 and cleaved-caspase-9 expression[1].
FASN-IN-8 (0.094-2.35 μM; 48 h) suppresses the PI3K/AKT signaling pathway in Hep-G2 cells in vitro in a concentration-dependent manner[1].
FASN-IN-8 (0.094-2.35 μM; 3 h) induces dose-dependent reactive oxygen species production in Hep-G2 cells at 0.094, 0.47, and 2.35 μM[1].
FASN-IN-8 (0.094-2.35 μM; 48 h) dose-dependently inhibits migration of Hep-G2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FASN-IN-8 Related Antibodies

Apoptosis Analysis[1]

Cell Line: human Hep-G2 hepatocellular carcinoma cells
Concentration: 0.094 μM, 0.47 μM, 2.35 μM
Incubation Time: 48 h (flow cytometry; Western blot)
Result: Significantly increased the proportion of apoptotic Hep-G2 cells in a concentration-dependent manner.
Upregulated expression of cleaved-caspase-3 and cleaved-caspase-9 in a concentration-dependent manner, indicating activation of caspase-dependent apoptotic pathways.

Western Blot Analysis[1]

Cell Line: human Hep-G2 hepatocellular carcinoma cells
Concentration: 0.094 μM, 0.47 μM, 2.35 μM
Incubation Time: 48 h
Result: Induced dose-dependent reductions in p-PI3K and p-AKT expression.
Caused significant decreases observed at 0.47 μM and 2.35 μM compared to control.
Molecular Weight

1038.10

Formula

C55H63N3O17
SMILES

O=C1C2=C(O)C([C@@H]3O[C@H](CO)[C@@H](O)[C@@H](O)[C@H]3O)=C(OCCCCC(NC4=CC=C(OC)C=C4)=O)C=C2OC5=C1C=C(OCCCCC(NC6=CC=C(OC)C=C6)=O)C(OCCCCC(NC7=CC=C(OC)C=C7)=O)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FASN-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FASN-IN-8Fatty Acid Synthase (FASN)Reactive Oxygen Species (ROS)ApoptosisPI3KAktCaspasePhosphoinositide 3-kinasePKBProtein kinase BHep-G2 cellsPI3K/AKT pathwayapoptosisfatty acid synthasehepatocellular carcinomaHUVECsHuh-7 cellsde novo lipogenesisreactive oxygen speciesFASNInhibitorinhibitorinhibit

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