1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. L-Sepiapterin

L-Sepiapterin (Synonyms: Sepiapterin)

Cat. No.: HY-112234
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L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression.

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L-Sepiapterin Chemical Structure

L-Sepiapterin Chemical Structure

CAS No. : 17094-01-8

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Description

L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

L-Sepiapterin (Sepiapterin) (0.1-10 μM; 24 hpurs) Iinduces cell proliferation in a dose-dependent manner[1].
L-Sepiapterin (1-50 μM; 20 minutes) significantly inhibits the phosphorylation of VEGF-A-induced (50 ng/ml) p70S6K[1].
L-Sepiapterin inhibits VEGF-A-induced cell proliferation and migration through NO-independent mechanism[1].

Cell Proliferation Assay[1]

Cell Line: SKOV-3 cells
Concentration: 0.1, 1, 10 μM
Incubation Time: 24 hours
Result: Induced cell proliferation in a dose-dependent manner.
In Vivo

Sepiapterin (10 mg/kg; p.o. (powder chow); daily for or 8 weeks) significantly improves the relaxation to Ach in small mesenteric arteries (SMA) from db/db mice[2].

Animal Model: Male C57BL/KsJ diabetic mice (db/db)[2]
Dosage: 10 mg/kg
Administration: P.o. (powder chow); daily for or 8 weeks
Result: Significantly improved the relaxation to Ach in SMA from db/db mice.
Molecular Weight

237.22

Formula

C₉H₁₁N₅O₃

CAS No.

17094-01-8

SMILES

O=C1NC(N)=NC2=C1N=C(C([[email protected]@H](O)C)=O)CN2

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Keywords:

L-SepiapterinSepiapterinEndogenous Metabolitedb/dbmiceangiogenesisp70S6KproliferationSKOV-3cellsovariancancerInhibitorinhibitorinhibit

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L-Sepiapterin
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