17094-01-8
Chemical Structure
L-Sepiapterin
Synonym(s): Sepiapterin; CNSA-001
- CAS No.: 17094-01-8
- Formula:C9H11N5O3
- Molecular Weight:237.22
IUPAC Name: (S)-2-amino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(3H)-one
InChIKey: VPVOXUSPXFPWBN-VKHMYHEASA-N
SMILES: O=C1NC(N)=NC2=C1N=C(C([C@@H](O)C)=O)CN2
Biological Activity: L-Sepiapterin (Sepiapterin), is a phenylalanine hydroxylase activator, is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. L-Sepiapterin can be used for the study of hyperphenylalaninemia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L-Sepiapterin | 90.48% | L-Sepiapterin (Sepiapterin), is a phenylalanine hydroxylase activator, is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. L-Sepiapterin can be used for the study of hyperphenylalaninemia. | ||||||||||||||||||||
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Similarity Score 0.72
HY-136341R7,8-Dihydroneopterin (Standard) -
Similarity Score 0.69
HY-W008646R7,8-Dihydro-L-biopterin (Standard) -
Similarity Score 0.58
HY-107383Tetrahydrobiopterin -
Similarity Score 0.58
HY-183638T7117 -
Similarity Score 0.58
HY-A0124Sapropterin -
Similarity Score 0.57
HY-A0124ARSapropterin dihydrochloride (Standard) -
Similarity Score 0.55
HY-W739789(6R)-Tetrahydro-L-biopterin sulfate -
Similarity Score 0.54
HY-144856S1Sapropterin-d3 -
Similarity Score 0.53
HY-117212Ronopterin -
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References
- [1]. Pannirselvam M, et al. Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice. Br J Pharmacol. 2003;140(4):701‐706. [Content Brief]
- [2]. Cho YR, et al. Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. Oncol Rep. 2011;26(4):861‐867. [Content Brief]
