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Art. -Nr.: HY-111636

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VSW1198

VSW1198 is an inhibitor for geranylgeranyl diphosphate synthase (GGDPS) with an IC₅₀ of 45 nM. VSW1198 reveals antitumor activity in myeloma- and prostate cancer with liver toxicity.

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Formel: C₁₅H₂₃N₃Na₄O₆P₂
Molecular Weight:495.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

VSW1198 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

VSW1198 is an inhibitor for geranylgeranyl diphosphate synthase (GGDPS) with an IC₅₀ of 45 nM. VSW1198 reveals antitumor activity in myeloma- and prostate cancer with liver toxicity^[1].

IC₅₀ & Target

IC₅₀: 45 nM (GGDPS)

Cellular Effect

Cell Line	Type	Value	Description	References
RPMI-8226	EC₅₀	0.19 μM Compound: 8	Cytotoxicity against human RPMI8226 after 48 hrs by MTT assay Cytotoxicity against human RPMI8226 after 48 hrs by MTT assay	[PMID: 26713103]

Chemical Information

Molecular Weight 495.27
Formel C₁₅H₂₃N₃Na₄O₆P₂
SMILES

O=P(O[Na])(O[Na])C(P(O[Na])(O[Na])=O)CC1=CN(CC/C=C(C)/CC/C=C(C)/C)N=N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Haney SL, Varney ML, Chhonker Y, Talmon G, Smith LM, Murry DJ, Holstein SA. In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway. Pharmacol Res. 2021 May;167:105528. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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