hGGPPS-IN-3
hGGPPS-IN-3 (Compound 13h) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-3 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-3 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo.
For research use only. We do not sell to patients.
- CAS No.: 2763223-96-5
- Formula: C21H19BrN4O7P2S
- Molecular Weight:613.31
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| RPMI-8226 | EC50 |
161 nM
Compound: 13h
|
Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell proliferation after 72 hrs by MTS assay
Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell proliferation after 72 hrs by MTS assay
|
[PMID: 35077178] |
Chemical Information
-
CAS No. 2763223-96-5
-
Molecular Weight 613.31
-
Formula C21H19BrN4O7P2S
-
SMILES
O=C(C1=CC(C2=NC3=C(C(NC(P(O)(O)=O)P(O)(O)=O)=N2)C=CS3)=CC=C1)NC4=CC(Br)=C(C=C4)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hGGPPS-IN-3 Related Classifications
HY-144130 Related Classifications
Powered by Bioz