2763223-96-5
Chemical Structure
hGGPPS-IN-3
- CAS No.: 2763223-96-5
- Formula:C21H19BrN4O7P2S
- Molecular Weight:613.31
IUPAC Name: (((2-(3-((3-bromo-4-methylphenyl)carbamoyl)phenyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)bis(phosphonic acid)
InChIKey: WULFKXIDSFBTSX-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C2=NC3=C(C(NC(P(O)(O)=O)P(O)(O)=O)=N2)C=CS3)=CC=C1)NC4=CC(Br)=C(C=C4)C
Biological Activity: hGGPPS-IN-3 (Compound 13h) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-3 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-3 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].
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hGGPPS-IN-3 | hGGPPS-IN-3 (Compound 13h) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-3 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-3 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo. | |||||||||||||||||||||
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Keywords
