Prosulfuron 

Prosulfuron is a fluorinated sulfonylurea herbicide with a reported acute oral LD₅₀ of 546 mg/kg in female rats. Prosulfuron acts by inhibiting acetolactate synthase (ALS) to block the biosynthesis of branched-chain amino acids (valine, leucine and isoleucine) in plants, thereby suppressing weed growth. Prosulfuron may disrupt the soil microbial community balance in alkaline soils with minimal chemical degradation. Prosulfuron has low toxicity to humans and mammals, and can be used for the research of broadleaf weed control in maize and sweet corn^[1][2].

Prosulfuron (2-10 μM) undergoes sulfonylurea bond cleavage during hydrolysis, chlorination, ozonation and UV photolysis, and undergoes aryl sulfonamide hydroxylation via hydroxyl radical reactions under UV/H₂O₂ treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

419.38

C₁₅H₁₆F₃N₅O₄S

94125-34-5

Solid

O=C(NC1=NC(=NC(=N1)C)OC)NS(=O)(=O)C=2C=CC=CC2CCC(F)(F)F

Room temperature in continental US; may vary elsewhere.

Store at room temperature 3 years

• [1]. Diakabou Oby RBM, et al. Exploring the behavior of fluorinated sulfonylureas herbicides, trifloxysulfuron and prosulfuron, under oxidative water treatment processes: Chlorination, ozonation, UV photolysis and hydroxyl radical reactions. J Hazard Mater. 2025;499:140273.  [Content Brief]

  [2]. Pampulha ME, et al. Impact of an herbicide combination of bromoxynil and prosulfuron on soil microorganisms. Curr Microbiol. 2006;53(3):238-243.  [Content Brief]