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  3. Pemetrexed-d5 disodium

Pemetrexed-d5 disodium  (Synonyms: LY231514-dd5 disodium)

Cat. No.: HY-10820AS
Handling Instructions

Pemetrexed-d5 (disodium) is the deuterium labeled Pemetrexed disodium. Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1].

For research use only. We do not sell to patients.

Pemetrexed-d<sub>5</sub> disodium Chemical Structure

Pemetrexed-d5 disodium Chemical Structure

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Description

Pemetrexed-d5 (disodium) is the deuterium labeled Pemetrexed disodium. Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

476.41

Formula

C20H14D5N5Na2O6

SMILES

O=C(O[Na])C([2H])([2H])C([2H])([2H])[C@](C(O[Na])=O)([2H])NC(C(C=C1)=CC=C1CCC2=CNC(NC(N)=N3)=C2C3=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Pemetrexed-d5 disodium
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HY-10820AS
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