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SMS2-IN-1 

Cat. No.: HY-102041
Handling Instructions

SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM).

For research use only. We do not sell to patients.

SMS2-IN-1 Chemical Structure

SMS2-IN-1 Chemical Structure

CAS No. : 2098890-15-2

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Description

SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM)[1].

IC50 & Target

IC50: 6.5 nM (SMS2), 1000 nM (SMS1)[1]
Kd: 37 nM (SMS2)[1]

In Vitro

AS/MS binding experiments are conducted using these SMS2-mutant membrane fractions, SMS2-IN-1 (compound 2) binds to the S217A, H272A, and D276A mutants. S227 and H229 are pivotal amino acid residues for the binding of SMS2-IN-1 to SMS2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

681.67

Formula

C₃₄H₃₇F₆N₃O₅

CAS No.

2098890-15-2

SMILES

O=C1C(C(N(CC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C)=O)=C(OCCCC3CCN(C(OC4(CC4)C)=O)CC3)C5=CC=CC=C5N1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SMS2-IN-1OthersSphingomyelinsynthaseSMS2S227H229Inhibitorinhibitorinhibit

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SMS2-IN-1
Cat. No.:
HY-102041
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