Multi-kinase-IN-13 

Multi-kinase-IN-13 (Compound 10F) is an inhibitor of AChE, BuChE, and GSK-3β, with an IC₅₀ of 3 nM against hAChE, 303 nM against hBuChE, and 7.58 nM against GSK-3β. Multi-kinase-IN-13 exhibits in vitro iron chelating activity. AChE-IN-110 can be used in the research of Alzheimer's disease^[1].

Multi-kinase-IN-13 (10 min) potently inhibits hAChE in vitro with an IC₅₀ of 3 nM, which is 2.3 times more potent than Donepezil (HY-14566)^[1].
Multi-kinase-IN-13 (0.003-10 μM) inhibits hBuChE in vitro, with an IC₅₀ of 303 nM^[1].
Multi-kinase-IN-13 potently inhibits GSK-3β in vitro with an IC₅₀ of 7.58 nM^[1].
Multi-kinase-IN-13 (0.003-10 mg/mL) exhibits in vitro iron chelating activity with an IC₅₀ value of 0.162 mg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

398.41

C₂₄H₁₈N₂O₄

O=C(NC1=CC=CC=C1)COC2=CC=C(C=C2)/C=N/C3=CC=C4OC(C=CC4=C3)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Emam NE, et al. Development of coumarin-based acetylcholinesterase inhibitors: Synthesis, biological assessment and computational simulations. Bioorg Chem. 2026;173:109630.  [Content Brief]