COASY Protein, Human (His)

COASY Protein, a bifunctional enzyme, plays a pivotal role in catalyzing the fourth and fifth steps of the CoA biosynthetic pathway. The coaD domain facilitates phosphopantetheine adenylyltransferase activity for the fourth reaction, and the coaE domain drives dephospho-CoA kinase activity for the fifth reaction. COASY is crucial for regulating CoA biosynthesis, ensuring efficient synthesis of the vital cofactor involved in diverse cellular metabolic pathways. COASY Protein, Human (His) is the recombinant human-derived COASY protein, expressed by E. coli, with N-His labeled tag. The total length of COASY Protein, Human (His) is 269 a.a., with molecular weight of ~33 kDa.

The COASY protein functions as a bifunctional enzyme, playing a pivotal role in catalyzing the fourth and fifth sequential steps of the CoA biosynthetic pathway. The phosphopantetheine adenylyltransferase activity, coded by the coaD domain, facilitates the fourth reaction, while the dephospho-CoA kinase activity, coded by the coaE domain, drives the fifth reaction in the pathway. This enzyme is integral to CoA biosynthesis regulation and may serve as a crucial point for controlling the overall process, ensuring the proper and efficient synthesis of CoA, a vital cofactor involved in various cellular metabolic pathways.

Human

E. coli

N-His

Q13057 (M296-D564)

80347  [NCBI]

Approximately 33 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.