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BPH-652 

Cat. No.: HY-16115
Handling Instructions

BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation).

For research use only. We do not sell to patients.

BPH-652 Chemical Structure

BPH-652 Chemical Structure

CAS No. : 157124-84-0

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Description

BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation)[1].

IC50 & Target

Ki: 1.5 nM (CrtM).
IC50: 100-300 nM (S. aureus pigment formation)[1].

In Vivo

BPH-652 treatment (0.5 mg twice per day (days −1, 0, 1, and 2), Intraperitoneal injection) significantly lowers S. aureus bacterial counts in the kidneys of the mice than those of the control group (P < 0.001), with 8 of 13 below the detection threshold, versus only 2 of 14 in the control group; on average, this result corresponds to a 98% decrease in surviving bacteria in the treatment group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A systemic S. aureus infection model in mice[1].
Dosage: 0.5 mg twice per day (days −1, 0, 1, and 2).
Administration: Intraperitoneal injection.
Result: S. aureus bacterial counts in the kidneys of the mice treated with BPH-652 were significantly lower than those of the control group.
Molecular Weight

500.63

Formula

C₁₆H₁₆K₃O₇PS

CAS No.

157124-84-0

SMILES

O=S(C(P(O[K])(O[K])=O)CCCC1=CC=CC(OC2=CC=CC=C2)=C1)(O[K])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BPH-652BPH652BPH 652OtherscholesterolInhibitorinhibitorinhibit

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BPH-652
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HY-16115
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