BPH-652
Based on 1 publication(s) in Google Scholar
BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation).
For research use only. We do not sell to patients.
- Purity: 98.97%
- CAS No.: 157124-84-0
- Formula: C16H16K3O7PS
- Molecular Weight:500.63
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) BPH-652
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Biological Activity
Ki: 1.5 nM (CrtM).
IC50: 100-300 nM (S. aureus pigment formation)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:A systemic S. aureus infection model in mice[1].
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Dosage:0.5 mg twice per day (days −1, 0, 1, and 2).
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Administration:Intraperitoneal injection.
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Result:S. aureus bacterial counts in the kidneys of the mice treated with BPH-652 were significantly lower than those of the control group.
Chemical Information
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CAS No. 157124-84-0
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Appearance Solid
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Molecular Weight 500.63
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Formula C16H16K3O7PS
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Color White to off-white
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SMILES
O=S(C(P(O[K])(O[K])=O)CCCC1=CC=CC(OC2=CC=CC=C2)=C1)(O[K])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet's disease. [Abstract]2024 Oct 26;15(1):9261. PMID: 39461948
Solvent & Solubility
H2O : 25 mg/mL (49.94 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.9975 mL | 9.9874 mL | 19.9748 mL | 49.9371 mL |
| 5 mM | 0.3995 mL | 1.9975 mL | 3.9950 mL | 9.9874 mL | |
| 10 mM | 0.1997 mL | 0.9987 mL | 1.9975 mL | 4.9937 mL | |
| 15 mM | 0.1332 mL | 0.6658 mL | 1.3317 mL | 3.3291 mL | |
| 20 mM | 0.0999 mL | 0.4994 mL | 0.9987 mL | 2.4969 mL | |
| 25 mM | 0.0799 mL | 0.3995 mL | 0.7990 mL | 1.9975 mL | |
| 30 mM | 0.0666 mL | 0.3329 mL | 0.6658 mL | 1.6646 mL | |
| 40 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 1.2484 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BPH-652 Related Classifications
HY-16115 Related Classifications
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