Xanthofulvin  (Synonyms: SM-216289)

Xanthofulvin (SM-216289) is an inhibitor of semaphorin 3A. Xanthofulvin blocks its binding to receptors, inhibits growth cone collapse, and accelerates olfactory nerve regeneration in rats in vivo. Xanthofulvin can be used in studies related to traumatic neuronal injury^[1][2].

Xanthofulvin (0-1 μg/mL; 2 h) potently inhibits Semaphorin3A (Sema3A)-induced growth cone collapse of E7 chicken dorsal root ganglion neurons cultured in vitro, with an IC₅₀ of 0.09 μg/mL, and does not alter the morphology of DRG cells in the absence of Sema3A^[1].
Xanthofulvin (0.16-2 μM; 0-2 h) potently inhibits Sema3A-induced growth cone collapse in E7 chicken dorsal root ganglion (DRG) explants, with an IC₅₀ of 0.16 μM, and completely blocks the collapse at concentrations below 2 μM^[2].
Xanthofulvin (0-4.0 μM; 0-2 days) dose-dependently blocks Sema3A-induced axonal repulsion in E8 chicken dorsal root ganglion (DRG) explants co-cultured with Sema3A-expressing COS7 cells^[2].
Xanthofulvin (5-500 μM; 48 h) exhibits no cytotoxicity against COS7 cells even at concentrations up to 500 μM with a 48 h incubation^[2].
Xanthofulvin inhibits the binding of Sema3A-AP to NP-1-expressing COS7 cells in a dose-dependent manner, with an IC₅₀ of 2.9 μM, and significantly reduces the binding at 5 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Xanthofulvin (6 μg/6 μL per day; continuous local administration at the injury site via cannula and osmotic pump) significantly accelerates olfactory nerve regeneration in axotomized rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

578.43

C₂₈H₁₈O₁₄

151466-15-8

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• [1]. Kumagai K, et al. Xanthofulvin, a novel semaphorin inhibitor produced by a strain of Penicillium. J Antibiot (Tokyo). 2003 Jul;56(7):610-6.  [Content Brief]

  [2]. Kikuchi K, et al. In vitro and in vivo characterization of a novel semaphorin 3A inhibitor, SM-216289 or xanthofulvin. J Biol Chem. 2003;278(44):42985-42991.  [Content Brief]