Xanthofulvin, a novel semaphorin inhibitor produced by a strain of Penicillium

  • J Antibiot (Tokyo). 2003 Jul;56(7):610-6. doi: 10.7164/antibiotics.56.610.
Kazuo Kumagai  1 ,  Nobuo Hosotani ,  Kaoru Kikuchi ,  Toru Kimura ,  Ikutaro Saji
Affiliations
  • 1. Exploratory Research Group, Research Division, Sumitomo Pharmaceuticals Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665-0051, Japan. [email protected]
PMID: 14513903 DOI: 10.7164/antibiotics.56.610
Abstract

A new semaphorin inhibitor xanthofulvin was isolated from the cultured broth of a fungus Penicillium sp. SPF-3059 along with a known compound vinaxanthone by solvent extraction and bioassay-guided fractionation. The tautomeric structure of xanthofulvin was determined by spectroscopic analyses. The two compounds exhibited significant semaphorin inhibitory activity with IC50 values of 0.09 and 0.1 microg/ml, respectively, in semaphorin3A-induced growth cone collapse assay using cultured chick dorsal root ganglia neurons.

Products