1. Immunology/Inflammation
  2. NO Synthase
  3. BBS-4

BBS-4 

Cat. No.: HY-12124
Handling Instructions

BBS-4 is a potent and selective inducible nitric oxide synthase (NOS2) dimerization inhibitor, with an IC50 of 0.49 nM. BBS-4 can protect mice from the cardiovascular dysfunction of sepsis.

For research use only. We do not sell to patients.

BBS-4 Chemical Structure

BBS-4 Chemical Structure

CAS No. : 402934-09-2

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Description

BBS-4 is a potent and selective inducible nitric oxide synthase (NOS2) dimerization inhibitor, with an IC50 of 0.49 nM. BBS-4 can protect mice from the cardiovascular dysfunction of sepsis[1].

IC50 & Target

IC50: 0.49 nM (NOS2)[1]

In Vitro

BBS-4 exhibits ∼300–2000-fold selective for inhibiting iNOS dimerization in cells versus CYP-3A4 (∼150 nM in a microsomal benzyloxyresorufin assay; ∼1 μM in a cell-based testosterone hydroxylase assay)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BBS-4 (10 mg/kg; i.p.; 1 h after endotoxin administration) prevents endotoxin-induced hypotension in mice[1].
BBS-4 (30 mg/kg; i.p.; 1 h after endotoxin administration) prevents endotoxin-induced myocardial dysfunction in mice[1].
BBS-4 (10 mg/kg; i.p.; 1 and 8 h after endotoxin administration) prevents endotoxin-induced impairment of murine hypoxic pulmonary vasoconstriction (HPV)[1].
BBS-4 (10 mg/kg; i.p.; 1 and 8 h after endotoxin administration) does not affect the endotoxin-induced increase in pulmonary NOS2 gene expression, but it (30 mg/kg) prevents cardiac and pulmonary NOS2 protein dimerization and increases plasma nitrate and nitrite (NOx) concentration in mice[1].
BBS-2 (30 mg/kg; s.c. twice daily for 10 d) does not affect agonist-stimulated NOS3-dependent aortic relaxation ex vivo[1].
BBS-4 (10-30 mg/kg; i.p.) does not improve mortality rate in endotoxemic mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

420.46

Formula

C₂₂H₂₄N₆O₃

CAS No.

402934-09-2

SMILES

O=C([[email protected]@H]1N(C2=NC(N3C=CN=C3)=NC(C)=C2)CCC1)NCCC4=CC=C(OCO5)C5=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BBS-4BBS4BBS 4NO SynthaseNitric oxide synthasesNOSinduciblenitricoxidesynthaseNOS2dimerizationsepsisInhibitorinhibitorinhibit

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