Mn(III) Protoporphyrin IX chloride  (Synonyms: Manganese(III) Protoporphyrin IX Chloride)

Mn(III) protoporphyrin IX chloride is a metalloporphyrin. It induces mRNA expression of the genes encoding δ-aminolevulinate synthase and heme oxygenase (HO), enzymes that catalyze the rate-limiting steps of heme biosynthesis and degradation, respectively, in chick embryo liver cells when used at a concentration of 10 μM. Mn(III) protoporphyrin IX chloride-containing nanobialys have been used in magnetic resonance imaging (MRI) of fibrin clots in vitro. It has also been used in the synthesis of Mn(III) protoporphyrin IX-6(7)-glycyl-glycyl-L-histidine methyl ester (MnGGH), a metalloporphyrin conjugate with microperoxidase activity.

651.03

C₃₄H₃₂ClMnN₄O₄

120389-54-0

Solid

Brown to black

O=C(CCC1=C(C)C2=[N]3C1=CC4=C(CCC([O-])=O)C(C)=C5C=C6C(C=C)=C(C)C(C=C7C(C=C)=C(C)C8=C2)=[N]6[Mn+3]3([N-]78)([N-]54)[Cl-])[O-].[H+].[H+]

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Cable, et al. Differential effects of metalloporphyrins on messenger RNA levels of δ-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells. J. Clin. Invest. 94(2), 649-654 (1994).