BMS-199264 hydrochloride 

BMS-199264 hydrochloride is an inhibitor of F1F0 ATP hydrolase (IC₅₀=0.5 μM) without inhibitory effect on F1F0 ATP synthase. BMS-199264 hydrochloride selectively inhibits ATP decline during ischemia to reduces cardiac necrosis. BMS-199264 hydrochloride also enhances the recovery of contractile function following reperfusion^[1].

BMS-199264 hydrochloride (1 μM, 3 μM, 10 μM) increases the time to onset of contracture and decreases LDH release, in a concentration-dependent manner in isolated rat hearts after a 25-min global ischemia followed by a 30-min reperfusion^[1].
BMS-199264 hydrochloride (3 μM) shows different effects on ATP synthase or hydrolase activity with values of 0.23 μM ATP/min/mg and 0.18 μM ATP/min/mg, respecctively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

567.53

C₂₆H₃₂Cl₂N₄O₄S

186180-83-6

O[C@@H]1C(C)(OC2=CC=C(C=C2[C@H]1N(CC3=NC=CN3)C4=CC=C(C=C4)Cl)S(=O)(N5CCCCC5)=O)C.Cl

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• [1]. Grover GJ, et al. Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia. Cardiovasc Ther. 2008 Winter;26(4):287-96.  [Content Brief]