186180-83-6
Chemical Structure
BMS-199264 hydrochloride
- CAS No.: 186180-83-6
- Formula:C26H32Cl2N4O4S
- Molecular Weight:567.53
IUPAC Name: (3S,4R)-4-(((1H-imidazol-2-yl)methyl)(4-chlorophenyl)amino)-2,2-dimethyl-6-(piperidin-1-ylsulfonyl)chroman-3-ol hydrochloride
InChIKey: CKNXQCNQMADQCI-KGQXAQPSSA-N
SMILES: O[C@@H]1C(C)(OC2=CC=C(C=C2[C@H]1N(CC3=NC=CN3)C4=CC=C(C=C4)Cl)S(=O)(N5CCCCC5)=O)C.Cl
Biological Activity: BMS-199264 hydrochloride is an inhibitor of F1F0 ATP hydrolase (IC50=0.5 μM) without inhibitory effect on F1F0 ATP synthase. BMS-199264 hydrochloride selectively inhibits ATP decline during ischemia to reduces cardiac necrosis. BMS-199264 hydrochloride also enhances the recovery of contractile function following reperfusion[1].
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BMS-199264 hydrochloride | 99.18% | BMS-199264 hydrochloride is an inhibitor of F1F0 ATP hydrolase (IC50=0.5 μM) without inhibitory effect on F1F0 ATP synthase. BMS-199264 hydrochloride selectively inhibits ATP decline during ischemia to reduces cardiac necrosis. BMS-199264 hydrochloride also enhances the recovery of contractile function following reperfusion. | ||||||||||||||||||||
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