2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. BMS-191095

BMS-191095 

Cat. No.: HY-14256 Purity: 98.06%
COA Handling Instructions

BMS-191095 is a selective activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels. BMS-191095 inhibits human platelet aggregation by opening mitochondrial K(ATP) channels.

For research use only. We do not sell to patients.

BMS-191095 Chemical Structure

BMS-191095 Chemical Structure

CAS No. : 166095-21-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 350 In-stock
Solution
10 mM * 1 mL in DMSO USD 350 In-stock
Solid
5 mg USD 320 In-stock
10 mg USD 450 In-stock
25 mg USD 890 In-stock
50 mg USD 1450 In-stock
100 mg USD 2200 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

BMS-191095 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE BMS-191095

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BMS-191095 is a selective activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels. BMS-191095 inhibits human platelet aggregation by opening mitochondrial K(ATP) channels[1][2][3].

In Vitro

BMS-191095 (50 μmol/L) induces mitochondrial depolarization of vascular smooth muscle (VSM) cells from SD rats[1].
BMS-191095 (10-100 μmol/L) dose-dependently induces vasodilation in endothelium denuded cerebral arteries[1].
BMS-191095 (50 μmol/L) increases the frequency of calcium sparks in VSM cells[1].
BMS-191095 (0-1500 μM) inhibits human platelet aggregation induced by collagen and thrombin with IC50 values of 63.9 and 104.8 μM, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-191095 Related Antibodies
In Vivo

BMS-191095 (2.5 or 25 μg; intraventricular infusion, 30 min/60 min/24 hours before the induction of ischemia, once) reduces neuronal damage in rats with transient focal cerebral ischemia[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats with the induction of ischemia induced by middle cerebral artery occlusion (MCAO)[3]
Dosage: 2.5 or 25 μg
Administration: Intraventricular infusion; 30 min/60 min/24 hours before the induction of ischemia, once
Result: Reduced total infarct volume in rats with of pretreat dose of 25 mg and 24 h before MCA. Induced a rapid mitochondrial depolarization.
Molecular Weight

408.88

Appearance

Solid

Formula

C22H21ClN4O2
CAS No.
SMILES

CC(O1)(C)[C@H](O)[C@@H](N(CC2=NC=CN2)C3=CC=C(Cl)C=C3)C4=C1C=CC(C#N)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (244.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4457 mL 12.2285 mL 24.4571 mL
5 mM 0.4891 mL 2.4457 mL 4.8914 mL
10 mM 0.2446 mL 1.2229 mL 2.4457 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (6.11 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (6.11 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.11 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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BMS-191095 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

BMS-191095166095-21-2BMS191095BMS 191095Potassium ChannelKcsAplatelet aggregationmitochondrial depolarizationVSMratcalcium sparkMCAOInhibitorinhibitorinhibit

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