1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. BMS-191095

BMS-191095 

Cat. No.: HY-14256 Purity: 98.06%
Handling Instructions

BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels.

For research use only. We do not sell to patients.

BMS-191095 Chemical Structure

BMS-191095 Chemical Structure

CAS No. : 166095-21-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 378 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1920 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels. Target: potassium channel in vitro: BMS-191095 induces mitochondrial-depolarization and vasodilation. BMS-191095 elicites a dose-dependent vasodilation in endothelium denuded cerebral arteries with 8.1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively. in vivo: In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels.

Molecular Weight

408.88

Formula

C₂₂H₂₁ClN₄O₂

CAS No.

166095-21-2

SMILES

CC(O1)(C)[[email protected]](O)[[email protected]@H](N(CC2=NC=CN2)C3=CC=C(Cl)C=C3)C4=C1C=CC(C#N)=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (122.29 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4457 mL 12.2285 mL 24.4571 mL
5 mM 0.4891 mL 2.4457 mL 4.8914 mL
10 mM 0.2446 mL 1.2229 mL 2.4457 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
BMS-191095
Cat. No.:
HY-14256
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