ATP Synthase C Antibody (YA2205)
(Synonyms: ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 1)ATP Synthase C Antibody (YA2205) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP Synthase C.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IP
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Reactivity :
Human, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:20 |
Product Details
ATP Synthase C Antibody (YA2205) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP Synthase C.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 14 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 14 kDa
SwissProt: P05496 Human ; Q06055 Human ; P48201 Human ;
OMIM: 603192 Human
A synthetic peptide of human ATP5G1/G2/G3 aa 98-110.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ATP Synthase C is a P05496: Subunit c, of the mitochondrial membrane ATP synthase complex (F (1) F (0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F (1) head domain - the catalytic core - and a membrane F (1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F (1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F (1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). With the subunit a (MT-ATP6), forms the proton-conducting channel in the F (0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix.
Q06055: Mitochondrial membrane ATP synthase (F (1) F (0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F (1) - containing the extramembraneous catalytic core and F (0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F (1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F (0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element
P48201: Mitochondrial membrane ATP synthase (F (1) F (0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F (1) - containing the extramembraneous catalytic core and F (0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F (1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F (0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element
[1]. -
Subcellular Localization
P05496: Mitochondrion membrane; Multi-pass membrane protein
Q06055: Mitochondrion membrane; Multi-pass membrane protein
P48201: Mitochondrion membrane; Multi-pass membrane protein -
Isoforms & Post-Translational Modification
Q06055 has 3 isomers: Q06055-1: 14637 Da (predicted); Q06055-2: 20513 Da (predicted); Q06055-3: 16334 Da (predicted).
Trimethylated by ATPSCKMT at Lys-109. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration -
Subunit
P05496: Homooctamer; the c-ring consists of eight c subunits forming a circle, and each subunit adopts a hairpin shape (PubMed:37244256).
Q06055: F-type ATPases have 2 components, CF (1) - the catalytic core - and CF (0) - the membrane proton channel. CF (1) has five subunits: alpha (3) , beta (3) , gamma (1) , delta (1) , epsilon (1). CF (0) has three main subunits: a, b and c (PubMed:8328972). Interacts with DNAJC30; interaction is direct (PubMed:30318146)
P48201: F-type ATPases have 2 components, CF (1) - the catalytic core - and CF (0) - the membrane proton channel. CF (1) has five subunits: alpha (3) , beta (3) , gamma (1) , delta (1) , epsilon (1). CF (0) has three main subunits: a, b and c. Interacts with TMEM70 and TMEM242 (PubMed:33753518) -
Synonyms
ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 1
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Research Field
Signal Transduction
Documentation
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