BRD-4592
BRD-4592 is an allosteric inhibitor targeting Mycobacterium tuberculosis tryptophan synthase (TrpAB). BRD-4592 binds at the α-β-subunit interface of TrpAB, with an IC50 of 70.9 nM for the α-subunit and 22.6 nM for the β-subunit.
For research use only. We do not sell to patients.
- CAS No.: 2119598-24-0
- Formula: C17H15FN2O
- Molecular Weight:282.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
>100 μM
Compound: BRD-4592
|
Cytotoxicity against human HepG2 cells
Cytotoxicity against human HepG2 cells
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[PMID: 31627992] |
Chemical Information
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CAS No. 2119598-24-0
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Molecular Weight 282.31
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Formula C17H15FN2O
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SMILES
N#C[C@H]1[C@H](C2=CC=C(C3=C(C=CC=C3)F)C=C2)[C@@H](N1)CO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BRD-4592 Related Classifications
HY-122016A Related Classifications
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