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  4. B3GNT6 Protein, Human (sf9, His)

B3GNT6 Protein, Human (sf9, His)

Cat. No.: HY-P76741
Handling Instructions

B3GNT6 Protein, a vital beta-1,3-N-acetylglucosaminyltransferase, is crucial for synthesizing the core 3 structure of O-glycans, essential in mucin-type glycoprotein biosynthesis. With a key role in digestive organs, B3GNT6 significantly contributes to glycoconjugate structural diversity and functional properties. Its involvement in core 3 O-glycan synthesis is vital for mucin formation, impacting cell adhesion and mucosal protection processes. Understanding B3GNT6's role enhances glycosylation pathway comprehension, with potential applications in digestive organ physiology and glycan-related therapeutic targets. Further investigation promises insights into mucin-type glycoprotein biosynthesis in health and disease. B3GNT6 Protein, Human (sf9, His) is the recombinant human-derived B3GNT6 protein, expressed by Sf9 insect cells, with N-His labeled tag. The total length of B3GNT6 Protein, Human (sf9, His) is 341 a.a., with molecular weight of ~47 kDa.

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Description

B3GNT6 Protein, a vital beta-1,3-N-acetylglucosaminyltransferase, is crucial for synthesizing the core 3 structure of O-glycans, essential in mucin-type glycoprotein biosynthesis. With a key role in digestive organs, B3GNT6 significantly contributes to glycoconjugate structural diversity and functional properties. Its involvement in core 3 O-glycan synthesis is vital for mucin formation, impacting cell adhesion and mucosal protection processes. Understanding B3GNT6's role enhances glycosylation pathway comprehension, with potential applications in digestive organ physiology and glycan-related therapeutic targets. Further investigation promises insights into mucin-type glycoprotein biosynthesis in health and disease. B3GNT6 Protein, Human (sf9, His) is the recombinant human-derived B3GNT6 protein, expressed by Sf9 insect cells, with N-His labeled tag. The total length of B3GNT6 Protein, Human (sf9, His) is 341 a.a., with molecular weight of ~47 kDa.

Background

The B3GNT6 Protein functions as a vital beta-1,3-N-acetylglucosaminyltransferase, specializing in the synthesis of the core 3 structure of O-glycans, which serves as a crucial precursor in the biosynthesis of mucin-type glycoproteins. With a key role in the synthesis of mucin-type O-glycans, particularly in digestive organs, B3GNT6 contributes significantly to the structural diversity and functional properties of glycoconjugates. The enzyme's involvement in core 3 O-glycan synthesis is essential for the proper formation and function of mucins, influencing processes related to cell adhesion and mucosal protection. Understanding the specific role of B3GNT6 enhances our comprehension of glycosylation pathways, offering potential applications in elucidating digestive organ physiology and contributing to the exploration of glycan-related therapeutic targets. Further investigation into B3GNT6's function holds promise for advancing our knowledge of mucin-type glycoprotein biosynthesis and its implications in health and disease.

Species

Human

Source

Sf9 insect cells

Tag

N-His

Accession

Q6ZMB0 (Q44-S384)

Gene ID
Molecular Construction
N-term
His
B3GNT6 (Q44-S384)
Accession # Q6ZMB0
C-term
Synonyms
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase; Core 3 synthase; Beta3Gn-T6
Molecular Weight

Approximately 47 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

B3GNT6 Protein, Human (sf9, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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B3GNT6 Protein, Human (sf9, His)
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