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Ibiglustat hydrochloride

(Synonyms: Venglustat hydrochloride; SAR402671 hydrochloride; GZ402671 hydrochloride)
3 Cited Publications
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Based on 3 publication(s) in Google Scholar

Ibiglustat hydrochloride is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat hydrochloride can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.

For research use only. We do not sell to patients.

  • CAS No.: 1629063-79-1
  • Formula: C20H25ClFN3O2S
  • Molecular Weight:425.95
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Ibiglustat hydrochloride Chemical Structure
    Ibiglustat hydrochloride Chemical Structure
  • Experimental Validation Results for Ibiglustat hydrochloride
  • Experimental Validation Results for Ibiglustat hydrochloride
  • Experimental Validation Results for Ibiglustat hydrochloride
  • Experimental Validation Results for Ibiglustat hydrochloride
  • Experimental Validation Results for Ibiglustat hydrochloride
CAS No.: 1629063-79-1
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609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Cell Proliferation/Viability AssayFlow CytometryWBIFHistological Imaging/Staining
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  • Histological Imaging/Staining
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  • Ibiglustat hydrochloride Chemical Structure
    Ibiglustat hydrochloride Chemical Structure
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    Ibiglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Jan:285:138303. [Abstract]

    Customer Validation
     CCK-8 assay evaluating the proliferation of PK-15 cells treated with UGCG inhibitors Ibiglustat (1.6-1000 nM) over 12-36 h.

  • 1/16

    Ibiglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Jan:285:138303. [Abstract]

    Customer Validation
     Flow cytometry analysis of PRV-GFP infection in PK-15 cells pretreated with UGCG inhibitors Eliglustat hemitartrate (1.6–1000 nM) and Ibiglustat (1.6–1000 nM) for 3 h, followed by GFP fluorescence intensity measurement 24 h post-infection to assess viral replication. The results showed that Ibiglustat significantly reduced PRV-GFP fluorescence signals in a dose-dependent manner.

  • 1/16

    Ibiglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Jan:285:138303. [Abstract]

    Customer Validation
     Ibiglustat (1.6–1000 nM; pretreated 3 h) reduced PRV-gB protein levels in a dose-dependent manner in PRV-QXX-infected PK-15 cells.

  • 1/16

    Ibiglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Jan:285:138303. [Abstract]

    Customer Validation
     Ibiglustat (1.6–1000 nM; 3 h) reduced PRV-gB protein levels in a dose-dependent manner in PRV-QXX-infected PK-15 cells.

  • 1/16

    Ibiglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Jan:285:138303. [Abstract]

    Customer Validation
     Brain, lung, liver, and spleen injury were assessed using hematoxylin and eosin staining 3 days post-infection (n = 3 per group). Histopathological examination revealed that PRV infection in mice induced proliferation of brain microglial cells, inflammatory cell infiltration in the lungs, significant thickening of alveolar septa, vacuolar degeneration of liver cells, and inflammatory tissue damage in the spleen. These pathological changes were attenuated by treatment with the UGCG inhibitors, Eliglustat hemitartrate or Ibiglustat ((2.5 mg/kg); s.c.; once daily for the first 3 days of PRV infection). Scale bar = 50 μm.

  • Ibiglustat hydrochloride