2. Neuronal Signaling
  3. Glucosylceramide Synthase (GCS)
  4. Ibiglustat hydrochloride

Ibiglustat hydrochloride  (Synonyms: Venglustat hydrochloride; SAR402671 hydrochloride; GZ402671 hydrochloride)

Cat. No.: HY-16743C
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Ibiglustat hydrochloride is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat hydrochloride can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.

For research use only. We do not sell to patients.

CAS No. : 1629063-79-1

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Top Publications Citing Use of Products
Cell Proliferation/Viability Assay
Flow Cytometry
WB
IF
Histological Imaging/Staining

    Ibiglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Dec 2:285:138303.  [Abstract]

    CCK-8 assay evaluating the proliferation of PK-15 cells treated with UGCG inhibitors Ibiglustat (1.6-1000 nM) over 12-36 h.

    Ibiglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Dec 2:285:138303.  [Abstract]

    Flow cytometry analysis of PRV-GFP infection in PK-15 cells pretreated with UGCG inhibitors Eliglustat hemitartrate (1.6–1000 nM) and Ibiglustat (1.6–1000 nM) for 3 h, followed by GFP fluorescence intensity measurement 24 h post-infection to assess viral replication. The results showed that Ibiglustat significantly reduced PRV-GFP fluorescence signals in a dose-dependent manner.

    Ibiglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Dec 2:285:138303.  [Abstract]

    Ibiglustat (1.6–1000 nM; pretreated 3 h) reduced PRV-gB protein levels in a dose-dependent manner in PRV-QXX-infected PK-15 cells.

    Ibiglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Dec 2:285:138303.  [Abstract]

    Ibiglustat (1.6–1000 nM; 3 h) reduced PRV-gB protein levels in a dose-dependent manner in PRV-QXX-infected PK-15 cells.

    Ibiglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Dec 2:285:138303.  [Abstract]

    Brain, lung, liver, and spleen injury were assessed using hematoxylin and eosin staining 3 days post-infection (n = 3 per group). Histopathological examination revealed that PRV infection in mice induced proliferation of brain microglial cells, inflammatory cell infiltration in the lungs, significant thickening of alveolar septa, vacuolar degeneration of liver cells, and inflammatory tissue damage in the spleen. These pathological changes were attenuated by treatment with the UGCG inhibitors, Eliglustat hemitartrate or Ibiglustat ((2.5 mg/kg); s.c.; once daily for the first 3 days of PRV infection). Scale bar = 50 μm.

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    Description

    Ibiglustat hydrochloride is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat hydrochloride can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease[1][2].

    Molecular Weight

    425.95

    Formula

    C20H25ClFN3O2S
    CAS No.
    SMILES

    O=C(O[C@H]1C2CCN(CC2)C1)NC(C)(C3=CSC(C4=CC=C(C=C4)F)=N3)C.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Ibiglustat hydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ibiglustat1629063-79-1VenglustatSAR402671GZ402671SAR 402671SAR-402671GZ 402671GZ-402671Glucosylceramide Synthase (GCS)GBAmutationsoralGL-3 levelsFabry diseaseParkinson's diseaseInhibitorinhibitorinhibit

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