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Ibiglustat (Synonyms: Venglustat; GZ/SAR402671; GZ402671; SAR402671)

Cat. No.: HY-16743 Purity: 98.08%
Handling Instructions

Ibiglustat is an inhibitor of glucosylceramide synthase extracted from patent WO 2015089067 A1, compound example 64.

For research use only. We do not sell to patients.

Ibiglustat Chemical Structure

Ibiglustat Chemical Structure

CAS No. : 1401090-53-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 206 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
2 mg USD 132 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 360 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 960 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 1440 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Ibiglustat is an inhibitor of glucosylceramide synthase extracted from patent WO 2015089067 A1, compound example 64.

In Vivo

Ibiglustat is in phase II clinical trials for the treatment of Fabry's disease. Fabry disease, an X-linked disorder of glycosphingolipids that is caused by mutations of the GLA gene that codes for α-galactosidase A, leads to dysfunction of many cell types and includes a systemic vasculopathy[2]. Substrate reduction therapy is an approach that reduces the synthesis of lipids reaching the lysosome through inhibition of glucosylceramide synthase (GCS)[1].

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.5675 mL 12.8373 mL 25.6746 mL
5 mM 0.5135 mL 2.5675 mL 5.1349 mL
10 mM 0.2567 mL 1.2837 mL 2.5675 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

389.49

Formula

C₂₀H₂₄FN₃O₂S

CAS No.

1401090-53-6

SMILES

O=C(O[[email protected]@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C=C4)=N3)C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 10 mM

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Ibiglustat
Cat. No.:
HY-16743
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