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  3. Ibiglustat L-Malic acid

Ibiglustat L-Malic acid (Synonyms: Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid))

Cat. No.: HY-16743A Purity: 98.07%
Handling Instructions

Ibiglustat L-Malic acid (Venglustat L-Malic acid), a potential therapy for PD Parkinson’s disease, SRT in Fabry’s and Gaucher’s, is a selective, allosteric inhibitor of glucosylceramide synthase (GCS) with ability to cross the blood-brain barrier.

For research use only. We do not sell to patients.

Ibiglustat L-Malic acid Chemical Structure

Ibiglustat L-Malic acid Chemical Structure

CAS No. : 1629063-78-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 230 In-stock
Estimated Time of Arrival: December 31
2 mg USD 100 In-stock
Estimated Time of Arrival: December 31
5 mg USD 200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 960 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Ibiglustat L-Malic acid:

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Description

Ibiglustat L-Malic acid (Venglustat L-Malic acid), a potential therapy for PD Parkinson’s disease, SRT in Fabry’s and Gaucher’s, is a selective, allosteric inhibitor of glucosylceramide synthase (GCS) with ability to cross the blood-brain barrier[1][2][3].

IC50 & Target

Glucosylceramide synthase[1].

In Vitro

Ibiglustat (SAR402671) (1 μM, 15 days) treated FD cells are close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes[4].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 102 mg/mL (194.82 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9100 mL 9.5498 mL 19.0996 mL
5 mM 0.3820 mL 1.9100 mL 3.8199 mL
10 mM 0.1910 mL 0.9550 mL 1.9100 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

523.57

Formula

C₂₄H₃₀FN₃O₇S

CAS No.

1629063-78-0

SMILES

O=C(O[[email protected]@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C=C4)=N3)C.OC(C[[email protected]](O)C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Ibiglustat L-Malic acid
Cat. No.:
HY-16743A
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Ibiglustat L-Malic acid

Cat. No.: HY-16743A